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Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review

BACKGROUND: Hepatic sarcomatoid carcinoma (HSC) is an extremely rare malignant tumor typically observed in clinical settings. HSC occurrence is predominantly noted in the right lobe and rarely in the left lobe of the liver. This report presents a case of sarcomatoid carcinoma that occurred in the le...

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Autores principales: Ma, Shuoshuo, Zhang, Dengyong, Zhao, Guanru, Ding, Sheng, Wu, Qiong, Zhang, Xueli, Lu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852497/
https://www.ncbi.nlm.nih.gov/pubmed/36684166
http://dx.doi.org/10.3389/fsurg.2022.1031284
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author Ma, Shuoshuo
Zhang, Dengyong
Zhao, Guanru
Ding, Sheng
Wu, Qiong
Zhang, Xueli
Lu, Zheng
author_facet Ma, Shuoshuo
Zhang, Dengyong
Zhao, Guanru
Ding, Sheng
Wu, Qiong
Zhang, Xueli
Lu, Zheng
author_sort Ma, Shuoshuo
collection PubMed
description BACKGROUND: Hepatic sarcomatoid carcinoma (HSC) is an extremely rare malignant tumor typically observed in clinical settings. HSC occurrence is predominantly noted in the right lobe and rarely in the left lobe of the liver. This report presents a case of sarcomatoid carcinoma that occurred in the left outer lobe of the liver, which was accompanied by gastrointestinal stromal tumors (GSTs) in the greater curvature of the stomach. In addition, the patient showed late-stage recurrence of HSC in gastric tissues. CASE PRESENTATION: A 63-year-old man was concomitantly diagnosed with HSC and GST. The main clinical manifestation was fever. Abdominal computer tomography (CT) and ultrasound-guided percutaneous liver biopsy at the local hospital revealed the presence of malignant hepatic tumors. The patient approached our hospital for further treatment. The subsequent electronic gastroscopy showed multiple submucosal tumors (SMT) in the stomach. Owing to the absence of multiple metastases in other regions of the body, we performed left hepatic lobe resection with gastric partial resection. The postoperative pathological analysis confirmed the presence of HSC and GST. The patient reported feeling well 1 month after the surgery, and no obvious space-occupying lesions in other areas were noted via imaging examinations. However, 3 months later, the patient presented with pain in the upper left abdomen, and examination revealed cancer recurrence in the stomach. The surgery was repeated, and the patient recovered favorably after the procedure. Unfortunately, the patient died owing to multiple metastatic diseases 4 months after the second surgical procedure. CONCLUSION: HSC shows no characteristic clinical manifestations and is highly malignant. Surgical intervention is the first treatment of choice for patients with HSC. In cases of sarcomatoid cancer occurring in the left lobe of the liver, it is imperative to exercise strict vigilance against the tumor's invasion of the stomach tissue. This is particularly important when the tumor breaks through the capsule of the liver.
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spelling pubmed-98524972023-01-21 Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review Ma, Shuoshuo Zhang, Dengyong Zhao, Guanru Ding, Sheng Wu, Qiong Zhang, Xueli Lu, Zheng Front Surg Surgery BACKGROUND: Hepatic sarcomatoid carcinoma (HSC) is an extremely rare malignant tumor typically observed in clinical settings. HSC occurrence is predominantly noted in the right lobe and rarely in the left lobe of the liver. This report presents a case of sarcomatoid carcinoma that occurred in the left outer lobe of the liver, which was accompanied by gastrointestinal stromal tumors (GSTs) in the greater curvature of the stomach. In addition, the patient showed late-stage recurrence of HSC in gastric tissues. CASE PRESENTATION: A 63-year-old man was concomitantly diagnosed with HSC and GST. The main clinical manifestation was fever. Abdominal computer tomography (CT) and ultrasound-guided percutaneous liver biopsy at the local hospital revealed the presence of malignant hepatic tumors. The patient approached our hospital for further treatment. The subsequent electronic gastroscopy showed multiple submucosal tumors (SMT) in the stomach. Owing to the absence of multiple metastases in other regions of the body, we performed left hepatic lobe resection with gastric partial resection. The postoperative pathological analysis confirmed the presence of HSC and GST. The patient reported feeling well 1 month after the surgery, and no obvious space-occupying lesions in other areas were noted via imaging examinations. However, 3 months later, the patient presented with pain in the upper left abdomen, and examination revealed cancer recurrence in the stomach. The surgery was repeated, and the patient recovered favorably after the procedure. Unfortunately, the patient died owing to multiple metastatic diseases 4 months after the second surgical procedure. CONCLUSION: HSC shows no characteristic clinical manifestations and is highly malignant. Surgical intervention is the first treatment of choice for patients with HSC. In cases of sarcomatoid cancer occurring in the left lobe of the liver, it is imperative to exercise strict vigilance against the tumor's invasion of the stomach tissue. This is particularly important when the tumor breaks through the capsule of the liver. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9852497/ /pubmed/36684166 http://dx.doi.org/10.3389/fsurg.2022.1031284 Text en © 2023 Ma, Zhang, Zhao, Ding, Wu, Zhang and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Ma, Shuoshuo
Zhang, Dengyong
Zhao, Guanru
Ding, Sheng
Wu, Qiong
Zhang, Xueli
Lu, Zheng
Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title_full Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title_fullStr Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title_full_unstemmed Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title_short Gastric infiltration of hepatic sarcomatoid carcinoma: A case report and literature review
title_sort gastric infiltration of hepatic sarcomatoid carcinoma: a case report and literature review
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852497/
https://www.ncbi.nlm.nih.gov/pubmed/36684166
http://dx.doi.org/10.3389/fsurg.2022.1031284
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