Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates

In nonhuman primates (NHPs), adeno-associated virus serotype 9 (AAV9) vectorized gene therapy can cause asymptomatic microscopic injury to dorsal root ganglia (DRG) and trigeminal ganglia (TG) somatosensory neurons, causing neurofilament light chain (NfL) to diffuse into cerebrospinal fluid (CSF) an...

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Detalles Bibliográficos
Autores principales: Johnson, Eric W., Sutherland, Jeffrey J., Meseck, Emily, McElroy, Cameron, Chand, Deepa H., Tukov, Francis Fonyuy, Hudry, Eloise, Penraat, Kelley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852542/
https://www.ncbi.nlm.nih.gov/pubmed/36700120
http://dx.doi.org/10.1016/j.omtm.2022.12.012

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