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Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) difference...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852709/ https://www.ncbi.nlm.nih.gov/pubmed/36685886 http://dx.doi.org/10.3389/fgene.2022.1067276 |
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author | Smederevac, Snežana Delgado-Cruzata, Lissette Mitrović, Dušanka Dinić, Bojana M. Bravo, Toni-Ann T. Delgado, Maria Bugarski Ignjatović, Vojislava Sadiković, Selka Milovanović, Ilija Vučinić, Nataša Branovački, Bojan Prinz, Mechthild Budimlija, Zoran Kušić‐Tišma, Jelena Nikolašević, Željka |
author_facet | Smederevac, Snežana Delgado-Cruzata, Lissette Mitrović, Dušanka Dinić, Bojana M. Bravo, Toni-Ann T. Delgado, Maria Bugarski Ignjatović, Vojislava Sadiković, Selka Milovanović, Ilija Vučinić, Nataša Branovački, Bojan Prinz, Mechthild Budimlija, Zoran Kušić‐Tišma, Jelena Nikolašević, Željka |
author_sort | Smederevac, Snežana |
collection | PubMed |
description | Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors. |
format | Online Article Text |
id | pubmed-9852709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98527092023-01-21 Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity Smederevac, Snežana Delgado-Cruzata, Lissette Mitrović, Dušanka Dinić, Bojana M. Bravo, Toni-Ann T. Delgado, Maria Bugarski Ignjatović, Vojislava Sadiković, Selka Milovanović, Ilija Vučinić, Nataša Branovački, Bojan Prinz, Mechthild Budimlija, Zoran Kušić‐Tišma, Jelena Nikolašević, Željka Front Genet Genetics Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9852709/ /pubmed/36685886 http://dx.doi.org/10.3389/fgene.2022.1067276 Text en Copyright © 2023 Smederevac, Delgado-Cruzata, Mitrović, Dinić, Bravo, Delgado, Bugarski Ignjatović, Sadiković, Milovanović, Vučinić, Branovački, Prinz, Budimlija, Kušić‐Tišma and Nikolašević. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Smederevac, Snežana Delgado-Cruzata, Lissette Mitrović, Dušanka Dinić, Bojana M. Bravo, Toni-Ann T. Delgado, Maria Bugarski Ignjatović, Vojislava Sadiković, Selka Milovanović, Ilija Vučinić, Nataša Branovački, Bojan Prinz, Mechthild Budimlija, Zoran Kušić‐Tišma, Jelena Nikolašević, Željka Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title | Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title_full | Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title_fullStr | Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title_full_unstemmed | Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title_short | Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity |
title_sort | differences in mb-comt dna methylation in monozygotic twins on phenotypic indicators of impulsivity |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852709/ https://www.ncbi.nlm.nih.gov/pubmed/36685886 http://dx.doi.org/10.3389/fgene.2022.1067276 |
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