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Functional evaluation of cyclosporine metabolism by CYP3A4 variants and potential drug interactions

The aim of this study is to investigate the effects of CYP3A4 genetic polymorphisms on the metabolism of cyclosporine (CsA) in vitro and identify drugs that interact with CsA. An enzymatic incubation system was developed to evaluate the kinetic parameters of CYP3A4 on CsA catalysis. A total of 132 d...

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Detalles Bibliográficos
Autores principales:	Kong, Qihui, Gao, Nanyong, Wang, Yahui, Hu, Guoxin, Qian, Jianchang, Chen, Bingbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852833/ https://www.ncbi.nlm.nih.gov/pubmed/36686709 http://dx.doi.org/10.3389/fphar.2022.1044817

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