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The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol
BACKGROUND: The use of lymph node (LN) tracers can help obtain a complete dissection of the lymph nodes and increase the detection rate of LNs and metastatic LNs. Carbon nanoparticle suspension injection (CNSI) and indocyanine green (ICG) have been widely used in radical gastrectomy in recent years....
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852878/ https://www.ncbi.nlm.nih.gov/pubmed/36686792 http://dx.doi.org/10.3389/fonc.2022.1044854 |
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author | Tian, Yuan Pang, Yue Yang, Peigang Guo, Honghai Liu, Yang Zhang, Ze Ding, Pingan Zheng, Tao Li, Yong Fan, Liqiao Zhang, Zhidong Zhao, Xuefeng Tan, Bibo Wang, Dong Zhao, Qun |
author_facet | Tian, Yuan Pang, Yue Yang, Peigang Guo, Honghai Liu, Yang Zhang, Ze Ding, Pingan Zheng, Tao Li, Yong Fan, Liqiao Zhang, Zhidong Zhao, Xuefeng Tan, Bibo Wang, Dong Zhao, Qun |
author_sort | Tian, Yuan |
collection | PubMed |
description | BACKGROUND: The use of lymph node (LN) tracers can help obtain a complete dissection of the lymph nodes and increase the detection rate of LNs and metastatic LNs. Carbon nanoparticle suspension injection (CNSI) and indocyanine green (ICG) have been widely used in radical gastrectomy in recent years. Nevertheless, the comparison of their clinical effects has not been studied. METHOD/DESIGN: The FUTURE-01 trial will be the first randomized, open-label, single-center trial to compare CNSI and ICG. The study started in 2021 and enrolled 96 patients according to a prior sample size calculation. The primary outcome is the number of LNs retrieved. The secondary outcomes are LN staining rate, LN metastasis rate, stained LN metastasis rate, perioperative recovery and survival. CONCLUSION: By comparing the safety and efficacy of CNSI and ICG tracer-guided LN dissection in patients with gastric cancer, we can determine the most appropriate LN tracer at present. With the help of LN tracers, the operation is simplified, and the prognosis of these patients is improved. Our study is a prospective exploration of the safety, efficacy, and prognosis of CNSI and ICG. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT05229874?cond=NCT05229874&draw=2&rank=1, identifier NCT05229874. |
format | Online Article Text |
id | pubmed-9852878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98528782023-01-21 The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol Tian, Yuan Pang, Yue Yang, Peigang Guo, Honghai Liu, Yang Zhang, Ze Ding, Pingan Zheng, Tao Li, Yong Fan, Liqiao Zhang, Zhidong Zhao, Xuefeng Tan, Bibo Wang, Dong Zhao, Qun Front Oncol Oncology BACKGROUND: The use of lymph node (LN) tracers can help obtain a complete dissection of the lymph nodes and increase the detection rate of LNs and metastatic LNs. Carbon nanoparticle suspension injection (CNSI) and indocyanine green (ICG) have been widely used in radical gastrectomy in recent years. Nevertheless, the comparison of their clinical effects has not been studied. METHOD/DESIGN: The FUTURE-01 trial will be the first randomized, open-label, single-center trial to compare CNSI and ICG. The study started in 2021 and enrolled 96 patients according to a prior sample size calculation. The primary outcome is the number of LNs retrieved. The secondary outcomes are LN staining rate, LN metastasis rate, stained LN metastasis rate, perioperative recovery and survival. CONCLUSION: By comparing the safety and efficacy of CNSI and ICG tracer-guided LN dissection in patients with gastric cancer, we can determine the most appropriate LN tracer at present. With the help of LN tracers, the operation is simplified, and the prognosis of these patients is improved. Our study is a prospective exploration of the safety, efficacy, and prognosis of CNSI and ICG. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT05229874?cond=NCT05229874&draw=2&rank=1, identifier NCT05229874. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9852878/ /pubmed/36686792 http://dx.doi.org/10.3389/fonc.2022.1044854 Text en Copyright © 2023 Tian, Pang, Yang, Guo, Liu, Zhang, Ding, Zheng, Li, Fan, Zhang, Zhao, Tan, Wang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Tian, Yuan Pang, Yue Yang, Peigang Guo, Honghai Liu, Yang Zhang, Ze Ding, Pingan Zheng, Tao Li, Yong Fan, Liqiao Zhang, Zhidong Zhao, Xuefeng Tan, Bibo Wang, Dong Zhao, Qun The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title | The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title_full | The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title_fullStr | The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title_full_unstemmed | The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title_short | The safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (FUTURE-01): A single-center randomized controlled trial protocol |
title_sort | safety and efficacy of carbon nanoparticle suspension injection versus indocyanine green tracer-guided lymph node dissection during radical gastrectomy (future-01): a single-center randomized controlled trial protocol |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852878/ https://www.ncbi.nlm.nih.gov/pubmed/36686792 http://dx.doi.org/10.3389/fonc.2022.1044854 |
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