Cargando…

Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy

BACKGROUND: Inflammatory conditions and oxidative stress increase in HIV infection, and inflammation increases the risk of cardiovascular disease. Ramadan fasting is known to reduce inflammation and oxidative stress in diabetic patients. This study examined the effects of Ramadan fasting on high-sen...

Descripción completa

Detalles Bibliográficos
Autores principales: Widhani, Alvina, Yunihastuti, Evy, Setiati, Siti, Witjaksono, Fiastuti, Karjadi, Teguh H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852883/
https://www.ncbi.nlm.nih.gov/pubmed/36687703
http://dx.doi.org/10.3389/fnut.2022.964797
_version_ 1784872761559089152
author Widhani, Alvina
Yunihastuti, Evy
Setiati, Siti
Witjaksono, Fiastuti
Karjadi, Teguh H.
author_facet Widhani, Alvina
Yunihastuti, Evy
Setiati, Siti
Witjaksono, Fiastuti
Karjadi, Teguh H.
author_sort Widhani, Alvina
collection PubMed
description BACKGROUND: Inflammatory conditions and oxidative stress increase in HIV infection, and inflammation increases the risk of cardiovascular disease. Ramadan fasting is known to reduce inflammation and oxidative stress in diabetic patients. This study examined the effects of Ramadan fasting on high-sensitivity C-reactive protein (hs-CRP) levels and total antioxidant status (TAOS) in HIV patients on antiretroviral therapy (ART). METHODS: This was a prospective cohort study comparing HIV-infected patients on stable ART who fasted throughout Ramadan to HIV-infected patients who did not fast during Ramadan. Inclusion criteria were men aged 20–40 years, taking first-line ART for at least 6 months, Muslims intent to fast for Ramadan, no current hospitalization because of acute conditions and not being treated for opportunistic infections. RESULTS: After 2 weeks, hs-CRP had decreased significantly in the fasting group (−0.41 mg/L [IQR = −1; 0.10]) compared to the non-fasting group (0.20 mg/L [IQR = −0.30; 1.50]) (p = 0.004). The linear regression analysis has shown that Ramadan fasting contributed to 10.10% of the variance in hs-CRP value (R(2) = 0.101) and decreased its value by 0.317 points (B = −0.317). Changes in TAOS did not significantly different (p = 0.405) between the fasting group (0.05 mmol/L [IQR = −0.03; 0.12]) and the non-fasting group (0.04 mmol/L [IQR = −0.13; 0.36]). In the fasting group, there were significant changes in polyunsaturated fatty acid consumption (p = 0.029), body weight (p = 0.001), cigarette smoking (p = 0.001), and sleeping duration (p = 0.001). CONCLUSION: Ramadan fasting reduces hs-CRP concentrations among HIV patients on ART.
format Online
Article
Text
id pubmed-9852883
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98528832023-01-21 Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy Widhani, Alvina Yunihastuti, Evy Setiati, Siti Witjaksono, Fiastuti Karjadi, Teguh H. Front Nutr Nutrition BACKGROUND: Inflammatory conditions and oxidative stress increase in HIV infection, and inflammation increases the risk of cardiovascular disease. Ramadan fasting is known to reduce inflammation and oxidative stress in diabetic patients. This study examined the effects of Ramadan fasting on high-sensitivity C-reactive protein (hs-CRP) levels and total antioxidant status (TAOS) in HIV patients on antiretroviral therapy (ART). METHODS: This was a prospective cohort study comparing HIV-infected patients on stable ART who fasted throughout Ramadan to HIV-infected patients who did not fast during Ramadan. Inclusion criteria were men aged 20–40 years, taking first-line ART for at least 6 months, Muslims intent to fast for Ramadan, no current hospitalization because of acute conditions and not being treated for opportunistic infections. RESULTS: After 2 weeks, hs-CRP had decreased significantly in the fasting group (−0.41 mg/L [IQR = −1; 0.10]) compared to the non-fasting group (0.20 mg/L [IQR = −0.30; 1.50]) (p = 0.004). The linear regression analysis has shown that Ramadan fasting contributed to 10.10% of the variance in hs-CRP value (R(2) = 0.101) and decreased its value by 0.317 points (B = −0.317). Changes in TAOS did not significantly different (p = 0.405) between the fasting group (0.05 mmol/L [IQR = −0.03; 0.12]) and the non-fasting group (0.04 mmol/L [IQR = −0.13; 0.36]). In the fasting group, there were significant changes in polyunsaturated fatty acid consumption (p = 0.029), body weight (p = 0.001), cigarette smoking (p = 0.001), and sleeping duration (p = 0.001). CONCLUSION: Ramadan fasting reduces hs-CRP concentrations among HIV patients on ART. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9852883/ /pubmed/36687703 http://dx.doi.org/10.3389/fnut.2022.964797 Text en Copyright © 2023 Widhani, Yunihastuti, Setiati, Witjaksono and Karjadi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Widhani, Alvina
Yunihastuti, Evy
Setiati, Siti
Witjaksono, Fiastuti
Karjadi, Teguh H.
Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title_full Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title_fullStr Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title_full_unstemmed Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title_short Ramadan fasting reduces high-sensitivity C-reactive protein among HIV-infected patients receiving antiretroviral therapy
title_sort ramadan fasting reduces high-sensitivity c-reactive protein among hiv-infected patients receiving antiretroviral therapy
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852883/
https://www.ncbi.nlm.nih.gov/pubmed/36687703
http://dx.doi.org/10.3389/fnut.2022.964797
work_keys_str_mv AT widhanialvina ramadanfastingreduceshighsensitivitycreactiveproteinamonghivinfectedpatientsreceivingantiretroviraltherapy
AT yunihastutievy ramadanfastingreduceshighsensitivitycreactiveproteinamonghivinfectedpatientsreceivingantiretroviraltherapy
AT setiatisiti ramadanfastingreduceshighsensitivitycreactiveproteinamonghivinfectedpatientsreceivingantiretroviraltherapy
AT witjaksonofiastuti ramadanfastingreduceshighsensitivitycreactiveproteinamonghivinfectedpatientsreceivingantiretroviraltherapy
AT karjaditeguhh ramadanfastingreduceshighsensitivitycreactiveproteinamonghivinfectedpatientsreceivingantiretroviraltherapy