A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic protein (B...

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Detalles Bibliográficos
Autores principales: Bhagwani, Aneel R., Ali, Mehboob, Piper, Bryce, Liu, Mingjun, Hudson, Jaylen, Kelly, Neil, Bogamuwa, Srimathi, Yang, Hu, Londino, James D., Bednash, Joseph S., Farkas, Daniela, Mallampalli, Rama K., Nicolls, Mark R., Ryan, John J., Thompson, A.A. Roger, Chan, Stephen Y., Gomez, Delphine, Goncharova, Elena A., Farkas, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852960/
https://www.ncbi.nlm.nih.gov/pubmed/36685041
http://dx.doi.org/10.1016/j.isci.2023.105935

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