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Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prol...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853036/ https://www.ncbi.nlm.nih.gov/pubmed/36686245 http://dx.doi.org/10.3389/fbioe.2022.1098986 |
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author | Zuo, Shuting Wang, Zhenyu Zhao, Liping Wang, Jing |
author_facet | Zuo, Shuting Wang, Zhenyu Zhao, Liping Wang, Jing |
author_sort | Zuo, Shuting |
collection | PubMed |
description | Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC. |
format | Online Article Text |
id | pubmed-9853036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98530362023-01-21 Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer Zuo, Shuting Wang, Zhenyu Zhao, Liping Wang, Jing Front Bioeng Biotechnol Bioengineering and Biotechnology Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853036/ /pubmed/36686245 http://dx.doi.org/10.3389/fbioe.2022.1098986 Text en Copyright © 2023 Zuo, Wang, Zhao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Zuo, Shuting Wang, Zhenyu Zhao, Liping Wang, Jing Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title | Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title_full | Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title_fullStr | Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title_full_unstemmed | Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title_short | Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
title_sort | gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853036/ https://www.ncbi.nlm.nih.gov/pubmed/36686245 http://dx.doi.org/10.3389/fbioe.2022.1098986 |
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