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Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer

Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prol...

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Autores principales: Zuo, Shuting, Wang, Zhenyu, Zhao, Liping, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853036/
https://www.ncbi.nlm.nih.gov/pubmed/36686245
http://dx.doi.org/10.3389/fbioe.2022.1098986
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author Zuo, Shuting
Wang, Zhenyu
Zhao, Liping
Wang, Jing
author_facet Zuo, Shuting
Wang, Zhenyu
Zhao, Liping
Wang, Jing
author_sort Zuo, Shuting
collection PubMed
description Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC.
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spelling pubmed-98530362023-01-21 Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer Zuo, Shuting Wang, Zhenyu Zhao, Liping Wang, Jing Front Bioeng Biotechnol Bioengineering and Biotechnology Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853036/ /pubmed/36686245 http://dx.doi.org/10.3389/fbioe.2022.1098986 Text en Copyright © 2023 Zuo, Wang, Zhao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zuo, Shuting
Wang, Zhenyu
Zhao, Liping
Wang, Jing
Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title_full Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title_fullStr Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title_full_unstemmed Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title_short Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
title_sort gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853036/
https://www.ncbi.nlm.nih.gov/pubmed/36686245
http://dx.doi.org/10.3389/fbioe.2022.1098986
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