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α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb

In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughou...

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Autores principales: Hu, Ruilong, Shankar, Janam, Dong, Grant Z., Villar, Pablo S., Araneda, Ricardo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853206/
https://www.ncbi.nlm.nih.gov/pubmed/36687519
http://dx.doi.org/10.3389/fncel.2022.1055569
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author Hu, Ruilong
Shankar, Janam
Dong, Grant Z.
Villar, Pablo S.
Araneda, Ricardo C.
author_facet Hu, Ruilong
Shankar, Janam
Dong, Grant Z.
Villar, Pablo S.
Araneda, Ricardo C.
author_sort Hu, Ruilong
collection PubMed
description In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughout life, providing a source of plasticity to the neural network of the OB. The function and integration of GCs in the OB are regulated by several afferent neuromodulatory signals, including noradrenaline (NA), a state-dependent neuromodulator that plays a crucial role in the regulation of cortical function and task-specific decision processes. However, the mechanisms by which NA regulates GC function are not fully understood. Here, we show that NA modulates hyperpolarization-activated currents (I(h)) via the activation of α(2)-adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. This modulation affects the dendrodendritic output of GCs leading to an enhancement of lateral inhibition onto the MCs. Furthermore, we show that NA modulates subthreshold resonance in GCs, which could affect the temporal integration of abGCs. Together, these results provide a novel mechanism by which a state-dependent neuromodulator acting on I(h) can regulate GC function in the OB.
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spelling pubmed-98532062023-01-21 α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb Hu, Ruilong Shankar, Janam Dong, Grant Z. Villar, Pablo S. Araneda, Ricardo C. Front Cell Neurosci Neuroscience In the olfactory bulb (OB), a large population of axon-less inhibitory interneurons, the granule cells (GCs), coordinate network activity and tune the output of principal neurons, the mitral and tufted cells (MCs), through dendrodendritic interactions. Furthermore, GCs undergo neurogenesis throughout life, providing a source of plasticity to the neural network of the OB. The function and integration of GCs in the OB are regulated by several afferent neuromodulatory signals, including noradrenaline (NA), a state-dependent neuromodulator that plays a crucial role in the regulation of cortical function and task-specific decision processes. However, the mechanisms by which NA regulates GC function are not fully understood. Here, we show that NA modulates hyperpolarization-activated currents (I(h)) via the activation of α(2)-adrenergic receptors (ARs) in adult-born GCs (abGCs), thus directly acting on channels that play essential roles in regulating neuronal excitability and network oscillations in the brain. This modulation affects the dendrodendritic output of GCs leading to an enhancement of lateral inhibition onto the MCs. Furthermore, we show that NA modulates subthreshold resonance in GCs, which could affect the temporal integration of abGCs. Together, these results provide a novel mechanism by which a state-dependent neuromodulator acting on I(h) can regulate GC function in the OB. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853206/ /pubmed/36687519 http://dx.doi.org/10.3389/fncel.2022.1055569 Text en Copyright © 2023 Hu, Shankar, Dong, Villar and Araneda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hu, Ruilong
Shankar, Janam
Dong, Grant Z.
Villar, Pablo S.
Araneda, Ricardo C.
α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title_full α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title_fullStr α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title_full_unstemmed α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title_short α(2)-Adrenergic modulation of I(h) in adult-born granule cells in the olfactory bulb
title_sort α(2)-adrenergic modulation of i(h) in adult-born granule cells in the olfactory bulb
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853206/
https://www.ncbi.nlm.nih.gov/pubmed/36687519
http://dx.doi.org/10.3389/fncel.2022.1055569
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