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Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes PCSK9–Dependent Adipose Insulin Resistance

Statin treatment is accepted to prevent adverse cardiovascular events. However, statin therapy has been reported to be dose-dependently associated with increased risk for new-onset type 2 diabetes mellitus (T2DM). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is expressed in adipose tissue a...

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Detalles Bibliográficos
Autores principales:	Shu, Xin, Wu, Jiaqi, Zhang, Tao, Ma, Xiaoyu, Du, Zuoqin, Xu, Jin, You, Jingcan, Wang, Liqun, Chen, Ni, Luo, Mao, Wu, Jianbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853319/ https://www.ncbi.nlm.nih.gov/pubmed/36558473 http://dx.doi.org/10.3390/nu14245314

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