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Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior

INTRODUCTION: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. METHODS: To further ex...

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Autores principales: Rigter, Pomme M. F., de Konink, Charlotte, van Woerden, Geeske M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853378/
https://www.ncbi.nlm.nih.gov/pubmed/36685241
http://dx.doi.org/10.3389/fnins.2022.1086994
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author Rigter, Pomme M. F.
de Konink, Charlotte
van Woerden, Geeske M.
author_facet Rigter, Pomme M. F.
de Konink, Charlotte
van Woerden, Geeske M.
author_sort Rigter, Pomme M. F.
collection PubMed
description INTRODUCTION: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. METHODS: To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse. RESULTS: We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment. DISCUSSION: Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment.
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spelling pubmed-98533782023-01-21 Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior Rigter, Pomme M. F. de Konink, Charlotte van Woerden, Geeske M. Front Neurosci Neuroscience INTRODUCTION: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. METHODS: To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse. RESULTS: We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment. DISCUSSION: Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853378/ /pubmed/36685241 http://dx.doi.org/10.3389/fnins.2022.1086994 Text en Copyright © 2023 Rigter, de Konink and van Woerden. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rigter, Pomme M. F.
de Konink, Charlotte
van Woerden, Geeske M.
Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title_full Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title_fullStr Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title_full_unstemmed Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title_short Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior
title_sort loss of camk2g affects intrinsic and motor behavior but has minimal impact on cognitive behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853378/
https://www.ncbi.nlm.nih.gov/pubmed/36685241
http://dx.doi.org/10.3389/fnins.2022.1086994
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