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Macrophage scavenger receptors: Tumor support and tumor inhibition

Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a large superfamily of multifunctional receptors t...

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Autores principales: Kazakova, Elena, Iamshchikov, Pavel, Larionova, Irina, Kzhyshkowska, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853406/
https://www.ncbi.nlm.nih.gov/pubmed/36686729
http://dx.doi.org/10.3389/fonc.2022.1096897
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author Kazakova, Elena
Iamshchikov, Pavel
Larionova, Irina
Kzhyshkowska, Julia
author_facet Kazakova, Elena
Iamshchikov, Pavel
Larionova, Irina
Kzhyshkowska, Julia
author_sort Kazakova, Elena
collection PubMed
description Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a large superfamily of multifunctional receptors that recognize, internalize and transport to the endosomal/lysosomal pathway apoptotic cells, cytokines, matrix molecules, lipid modified lipoproteins and other unwanted-self ligands. In our review, we summarized state-of-the art for the role of macrophage scavenger receptors in tumor development and their significance as cancer biomarkers. In this review we focused on functional activity of TAM-expressing SRs in animal models and in patients, and summarized the data for different human cancer types about the prognostic significance of TAM-expressed SRs. We discussed the role of SRs in the regulation of cancer cell biology, cell-cell and cell-matrix interaction in TME, immune status in TME, angiogenesis, and intratumoral metabolism. Targeting of tumor-promoting SRs can be a promising therapeutic approach in anti-cancer therapy. In our review we provide evidence for both tumor supporting and tumor inhibiting functions of scavenger receptors expressed on TAMs. We focused on the key differences in the prognostic and functional roles of SRs that are specific for cancer types. We highlighted perspectives for inhibition of tumor-promoting SRs in anti-cancer therapy.
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spelling pubmed-98534062023-01-21 Macrophage scavenger receptors: Tumor support and tumor inhibition Kazakova, Elena Iamshchikov, Pavel Larionova, Irina Kzhyshkowska, Julia Front Oncol Oncology Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a large superfamily of multifunctional receptors that recognize, internalize and transport to the endosomal/lysosomal pathway apoptotic cells, cytokines, matrix molecules, lipid modified lipoproteins and other unwanted-self ligands. In our review, we summarized state-of-the art for the role of macrophage scavenger receptors in tumor development and their significance as cancer biomarkers. In this review we focused on functional activity of TAM-expressing SRs in animal models and in patients, and summarized the data for different human cancer types about the prognostic significance of TAM-expressed SRs. We discussed the role of SRs in the regulation of cancer cell biology, cell-cell and cell-matrix interaction in TME, immune status in TME, angiogenesis, and intratumoral metabolism. Targeting of tumor-promoting SRs can be a promising therapeutic approach in anti-cancer therapy. In our review we provide evidence for both tumor supporting and tumor inhibiting functions of scavenger receptors expressed on TAMs. We focused on the key differences in the prognostic and functional roles of SRs that are specific for cancer types. We highlighted perspectives for inhibition of tumor-promoting SRs in anti-cancer therapy. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853406/ /pubmed/36686729 http://dx.doi.org/10.3389/fonc.2022.1096897 Text en Copyright © 2023 Kazakova, Iamshchikov, Larionova and Kzhyshkowska https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kazakova, Elena
Iamshchikov, Pavel
Larionova, Irina
Kzhyshkowska, Julia
Macrophage scavenger receptors: Tumor support and tumor inhibition
title Macrophage scavenger receptors: Tumor support and tumor inhibition
title_full Macrophage scavenger receptors: Tumor support and tumor inhibition
title_fullStr Macrophage scavenger receptors: Tumor support and tumor inhibition
title_full_unstemmed Macrophage scavenger receptors: Tumor support and tumor inhibition
title_short Macrophage scavenger receptors: Tumor support and tumor inhibition
title_sort macrophage scavenger receptors: tumor support and tumor inhibition
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853406/
https://www.ncbi.nlm.nih.gov/pubmed/36686729
http://dx.doi.org/10.3389/fonc.2022.1096897
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