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Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease

The repetitive transcranial magnetic stimulation (rTMS) shows great potential in the treatment of Alzheimer’s disease (AD). However, its treatment efficacy for AD patients in moderate to severe stage is relatively evaluated. Here, we proposed a randomized, sham-controlled, clinical trial of rTMS amo...

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Autores principales: Zhang, Shouzi, Liu, Lixin, Zhang, Li, Ma, Li, Wu, Haiyan, He, Xuelin, Cao, Meng, Li, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853407/
https://www.ncbi.nlm.nih.gov/pubmed/36688172
http://dx.doi.org/10.3389/fnagi.2022.1070535
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author Zhang, Shouzi
Liu, Lixin
Zhang, Li
Ma, Li
Wu, Haiyan
He, Xuelin
Cao, Meng
Li, Rui
author_facet Zhang, Shouzi
Liu, Lixin
Zhang, Li
Ma, Li
Wu, Haiyan
He, Xuelin
Cao, Meng
Li, Rui
author_sort Zhang, Shouzi
collection PubMed
description The repetitive transcranial magnetic stimulation (rTMS) shows great potential in the treatment of Alzheimer’s disease (AD). However, its treatment efficacy for AD patients in moderate to severe stage is relatively evaluated. Here, we proposed a randomized, sham-controlled, clinical trial of rTMS among 35 moderate-to-severe AD patients. A high frequency (10 Hz) stimulation of the left dorsal lateral prefrontal cortex (DLPFC), 60-session long treatment lasting for 3 months procedure was adopted in the trial. Each participant completed a battery of neuropsychological tests at baseline and post-treatment for evaluation of the rTMS therapeutic effect. Twelve of them completed baseline resting-state functional magnetic resonance imaging (fMRI) for exploration of the underlying neural contribution to individual difference in treatment outcomes. The result showed that the rTMS treatment significantly improved cognitive performance on the severe impairment battery (SIB), reduced psychiatric symptoms on the neuropsychiatric inventory (NPI), and improved the clinician’s global impression of change (CIBIC-Plus). Furthermore, the result preliminarily proposed resting-state multivariate functional connectivity in the (para) hippocampal region as well as two clusters in the frontal and occipital cortices as a pre-treatment neuroimaging marker for predicting individual differences in treatment outcomes. The finding could brought some enlightenment and reference for the rTMS treatment of moderate and severe AD patients.
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spelling pubmed-98534072023-01-21 Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease Zhang, Shouzi Liu, Lixin Zhang, Li Ma, Li Wu, Haiyan He, Xuelin Cao, Meng Li, Rui Front Aging Neurosci Aging Neuroscience The repetitive transcranial magnetic stimulation (rTMS) shows great potential in the treatment of Alzheimer’s disease (AD). However, its treatment efficacy for AD patients in moderate to severe stage is relatively evaluated. Here, we proposed a randomized, sham-controlled, clinical trial of rTMS among 35 moderate-to-severe AD patients. A high frequency (10 Hz) stimulation of the left dorsal lateral prefrontal cortex (DLPFC), 60-session long treatment lasting for 3 months procedure was adopted in the trial. Each participant completed a battery of neuropsychological tests at baseline and post-treatment for evaluation of the rTMS therapeutic effect. Twelve of them completed baseline resting-state functional magnetic resonance imaging (fMRI) for exploration of the underlying neural contribution to individual difference in treatment outcomes. The result showed that the rTMS treatment significantly improved cognitive performance on the severe impairment battery (SIB), reduced psychiatric symptoms on the neuropsychiatric inventory (NPI), and improved the clinician’s global impression of change (CIBIC-Plus). Furthermore, the result preliminarily proposed resting-state multivariate functional connectivity in the (para) hippocampal region as well as two clusters in the frontal and occipital cortices as a pre-treatment neuroimaging marker for predicting individual differences in treatment outcomes. The finding could brought some enlightenment and reference for the rTMS treatment of moderate and severe AD patients. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853407/ /pubmed/36688172 http://dx.doi.org/10.3389/fnagi.2022.1070535 Text en Copyright © 2023 Zhang, Liu, Zhang, Ma, Wu, He, Cao and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Zhang, Shouzi
Liu, Lixin
Zhang, Li
Ma, Li
Wu, Haiyan
He, Xuelin
Cao, Meng
Li, Rui
Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title_full Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title_fullStr Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title_full_unstemmed Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title_short Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer’s disease
title_sort evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe alzheimer’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853407/
https://www.ncbi.nlm.nih.gov/pubmed/36688172
http://dx.doi.org/10.3389/fnagi.2022.1070535
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