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BRAF L485–P490 deletion mutant metastatic melanoma sensitive to BRAF and MEK inhibition: A case report and literature review

Background: The combination therapy of BRAF inhibitors (BRAFis) and MEK inhibitors (MEKis) has been approved as a first-line treatment for metastatic melanoma with BRAF V600 mutants. Recently, BRAF mutations have been divided into three subtypes based on biochemical and signaling characteristics. Un...

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Detalles Bibliográficos
Autores principales:	Zhang, Simeng, Yang, Zichang, Cheng, Yu, Guo, Xiaoyu, Liu, Chang, Wang, Shuo, Zhang, Lingyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853440/ https://www.ncbi.nlm.nih.gov/pubmed/36686670 http://dx.doi.org/10.3389/fphar.2022.1019217

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