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Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments
[Image: see text] Over the past 40 years, structural and dynamic DNA nanotechnologies have undoubtedly demonstrated to be effective means for organizing matter at the nanoscale and reconfiguring equilibrium structures, in a predictable fashion and with an accuracy of a few nanometers. Recently, nove...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853505/ https://www.ncbi.nlm.nih.gov/pubmed/36174970 http://dx.doi.org/10.1021/acs.bioconjchem.2c00312 |
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author | Stenke, Lena J. Saccà, Barbara |
author_facet | Stenke, Lena J. Saccà, Barbara |
author_sort | Stenke, Lena J. |
collection | PubMed |
description | [Image: see text] Over the past 40 years, structural and dynamic DNA nanotechnologies have undoubtedly demonstrated to be effective means for organizing matter at the nanoscale and reconfiguring equilibrium structures, in a predictable fashion and with an accuracy of a few nanometers. Recently, novel concepts and methodologies have been developed to integrate nonequilibrium dynamics into DNA nanostructures, opening the way to the construction of synthetic materials that can adapt to environmental changes and thus acquire new properties. In this Review, we summarize the strategies currently applied for the construction of synthetic DNA filaments and conclude by reporting some recent and most relevant examples of DNA filaments that can emulate typical structural and dynamic features of the cytoskeleton, such as compartmentalization in cell-like vesicles, support for active transport of cargos, sustained or transient growth, and responsiveness to external stimuli. |
format | Online Article Text |
id | pubmed-9853505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-98535052023-01-21 Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments Stenke, Lena J. Saccà, Barbara Bioconjug Chem [Image: see text] Over the past 40 years, structural and dynamic DNA nanotechnologies have undoubtedly demonstrated to be effective means for organizing matter at the nanoscale and reconfiguring equilibrium structures, in a predictable fashion and with an accuracy of a few nanometers. Recently, novel concepts and methodologies have been developed to integrate nonequilibrium dynamics into DNA nanostructures, opening the way to the construction of synthetic materials that can adapt to environmental changes and thus acquire new properties. In this Review, we summarize the strategies currently applied for the construction of synthetic DNA filaments and conclude by reporting some recent and most relevant examples of DNA filaments that can emulate typical structural and dynamic features of the cytoskeleton, such as compartmentalization in cell-like vesicles, support for active transport of cargos, sustained or transient growth, and responsiveness to external stimuli. American Chemical Society 2022-09-29 /pmc/articles/PMC9853505/ /pubmed/36174970 http://dx.doi.org/10.1021/acs.bioconjchem.2c00312 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Stenke, Lena J. Saccà, Barbara Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments |
title | Design, Mechanical Properties, and Dynamics of Synthetic
DNA Filaments |
title_full | Design, Mechanical Properties, and Dynamics of Synthetic
DNA Filaments |
title_fullStr | Design, Mechanical Properties, and Dynamics of Synthetic
DNA Filaments |
title_full_unstemmed | Design, Mechanical Properties, and Dynamics of Synthetic
DNA Filaments |
title_short | Design, Mechanical Properties, and Dynamics of Synthetic
DNA Filaments |
title_sort | design, mechanical properties, and dynamics of synthetic
dna filaments |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853505/ https://www.ncbi.nlm.nih.gov/pubmed/36174970 http://dx.doi.org/10.1021/acs.bioconjchem.2c00312 |
work_keys_str_mv | AT stenkelenaj designmechanicalpropertiesanddynamicsofsyntheticdnafilaments AT saccabarbara designmechanicalpropertiesanddynamicsofsyntheticdnafilaments |