Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System

[Image: see text] Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs, the choice of the antigens’ analogues and multivalent presentation have been proved to be successful. Here, w...

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Autores principales: Fallarini, Silvia, Papi, Francesco, Licciardi, Federico, Natali, Francesca, Lombardi, Grazia, Maestrelli, Francesca, Nativi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853506/
https://www.ncbi.nlm.nih.gov/pubmed/36519843
http://dx.doi.org/10.1021/acs.bioconjchem.2c00383
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author Fallarini, Silvia
Papi, Francesco
Licciardi, Federico
Natali, Francesca
Lombardi, Grazia
Maestrelli, Francesca
Nativi, Cristina
author_facet Fallarini, Silvia
Papi, Francesco
Licciardi, Federico
Natali, Francesca
Lombardi, Grazia
Maestrelli, Francesca
Nativi, Cristina
author_sort Fallarini, Silvia
collection PubMed
description [Image: see text] Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs, the choice of the antigens’ analogues and multivalent presentation have been proved to be successful. Here, we present the preparation, characterization, and in vitro screening of niosomes displaying multiple copies of the mucin antigen TnThr (niosomes-7) or of TnThr mimetic 1 (niosomes-2). Unprecedentedly, structural differences, likely related to the carbohydrate portions, were observed for the two colloidal systems. Both niosomal systems are stable, nontoxic and endowed with promising immunogenic properties.
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spelling pubmed-98535062023-01-21 Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System Fallarini, Silvia Papi, Francesco Licciardi, Federico Natali, Francesca Lombardi, Grazia Maestrelli, Francesca Nativi, Cristina Bioconjug Chem [Image: see text] Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs, the choice of the antigens’ analogues and multivalent presentation have been proved to be successful. Here, we present the preparation, characterization, and in vitro screening of niosomes displaying multiple copies of the mucin antigen TnThr (niosomes-7) or of TnThr mimetic 1 (niosomes-2). Unprecedentedly, structural differences, likely related to the carbohydrate portions, were observed for the two colloidal systems. Both niosomal systems are stable, nontoxic and endowed with promising immunogenic properties. American Chemical Society 2022-12-15 /pmc/articles/PMC9853506/ /pubmed/36519843 http://dx.doi.org/10.1021/acs.bioconjchem.2c00383 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Fallarini, Silvia
Papi, Francesco
Licciardi, Federico
Natali, Francesca
Lombardi, Grazia
Maestrelli, Francesca
Nativi, Cristina
Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title_full Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title_fullStr Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title_full_unstemmed Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title_short Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
title_sort niosomes as biocompatible scaffolds for the multivalent presentation of tumor-associated antigens (tacas) to the immune system
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853506/
https://www.ncbi.nlm.nih.gov/pubmed/36519843
http://dx.doi.org/10.1021/acs.bioconjchem.2c00383
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