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Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’

Subependymal Giant Cell Astrocytoma (SEGA) is a common diagnosis in patients with Tuberous Sclerosis. Although surgical treatment is often required, resection may entail a significant risk for cognitive function given the anatomical relation with critical structures such as the fornices and subgenua...

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Autores principales: Ghani, Imran, Patel, Sabina, Ghimire, Prajwal, Bodi, Istvan, Bhangoo, Ranjeev, Vergani, Francesco, Ashkan, Keyoumars, Lavrador, Jose Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853524/
https://www.ncbi.nlm.nih.gov/pubmed/36684213
http://dx.doi.org/10.3389/fsurg.2022.1065979
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author Ghani, Imran
Patel, Sabina
Ghimire, Prajwal
Bodi, Istvan
Bhangoo, Ranjeev
Vergani, Francesco
Ashkan, Keyoumars
Lavrador, Jose Pedro
author_facet Ghani, Imran
Patel, Sabina
Ghimire, Prajwal
Bodi, Istvan
Bhangoo, Ranjeev
Vergani, Francesco
Ashkan, Keyoumars
Lavrador, Jose Pedro
author_sort Ghani, Imran
collection PubMed
description Subependymal Giant Cell Astrocytoma (SEGA) is a common diagnosis in patients with Tuberous Sclerosis. Although surgical treatment is often required, resection may entail a significant risk for cognitive function given the anatomical relation with critical structures such as the fornices and subgenual area. Therefore, target subtotal resections using minimal invasive approaches focused in the higher metabolic areas are valuable options to preserve quality of life while addressing specific problems caused by the tumor, such as hydrocephalus or progressive growth of a specific component of the tumor. In this report, the authors explore the potential role of 5-ALA in the identification of highly metabolic areas during SEGA resection in the context of minimal invasive approaches.
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spelling pubmed-98535242023-01-21 Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’ Ghani, Imran Patel, Sabina Ghimire, Prajwal Bodi, Istvan Bhangoo, Ranjeev Vergani, Francesco Ashkan, Keyoumars Lavrador, Jose Pedro Front Surg Surgery Subependymal Giant Cell Astrocytoma (SEGA) is a common diagnosis in patients with Tuberous Sclerosis. Although surgical treatment is often required, resection may entail a significant risk for cognitive function given the anatomical relation with critical structures such as the fornices and subgenual area. Therefore, target subtotal resections using minimal invasive approaches focused in the higher metabolic areas are valuable options to preserve quality of life while addressing specific problems caused by the tumor, such as hydrocephalus or progressive growth of a specific component of the tumor. In this report, the authors explore the potential role of 5-ALA in the identification of highly metabolic areas during SEGA resection in the context of minimal invasive approaches. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853524/ /pubmed/36684213 http://dx.doi.org/10.3389/fsurg.2022.1065979 Text en © 2023 Ghani, Patel, Ghimire, Bodi, Bhangoo, Vergani, Ashkan and Lavrador. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Ghani, Imran
Patel, Sabina
Ghimire, Prajwal
Bodi, Istvan
Bhangoo, Ranjeev
Vergani, Francesco
Ashkan, Keyoumars
Lavrador, Jose Pedro
Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title_full Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title_fullStr Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title_full_unstemmed Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title_short Case report: ‘Photodynamics of Subependymal Giant Cell Astrocytoma with 5-Aminolevulinic acid’
title_sort case report: ‘photodynamics of subependymal giant cell astrocytoma with 5-aminolevulinic acid’
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853524/
https://www.ncbi.nlm.nih.gov/pubmed/36684213
http://dx.doi.org/10.3389/fsurg.2022.1065979
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