Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder

BACKGROUND: A large and growing body of neuroimaging research has concentrated on patients with attention-deficit/hyperactivity disorder (ADHD), but with inconsistent conclusions. This article was intended to investigate the common and certain neural alterations in the structure and function of the...

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Autores principales: Yu, Miaomiao, Gao, Xinyu, Niu, Xiaoyu, Zhang, Mengzhe, Yang, Zhengui, Han, Shaoqiang, Cheng, Jingliang, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853532/
https://www.ncbi.nlm.nih.gov/pubmed/36683981
http://dx.doi.org/10.3389/fpsyt.2022.1070142
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author Yu, Miaomiao
Gao, Xinyu
Niu, Xiaoyu
Zhang, Mengzhe
Yang, Zhengui
Han, Shaoqiang
Cheng, Jingliang
Zhang, Yong
author_facet Yu, Miaomiao
Gao, Xinyu
Niu, Xiaoyu
Zhang, Mengzhe
Yang, Zhengui
Han, Shaoqiang
Cheng, Jingliang
Zhang, Yong
author_sort Yu, Miaomiao
collection PubMed
description BACKGROUND: A large and growing body of neuroimaging research has concentrated on patients with attention-deficit/hyperactivity disorder (ADHD), but with inconsistent conclusions. This article was intended to investigate the common and certain neural alterations in the structure and function of the brain in patients with ADHD and further explore the differences in brain alterations between adults and children with ADHD. METHODS: We conducted an extensive literature search of whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies associated with ADHD. Two separate meta-analyses with the seed-based d mapping software package for functional neural activation and gray matter volume (GMV) were carried out, followed by a joint analysis and a subgroup analysis. RESULTS: This analysis included 29 VBM studies and 36 fMRI studies. Structurally, VBM analysis showed that the largest GMV diminutions in patients with ADHD were in several frontal-parietal brain regions, the limbic system, and the corpus callosum. Functionally, fMRI analysis discovered significant hypoactivation in several frontal-temporal brain regions, the right postcentral gyrus, the left insula, and the corpus callosum. CONCLUSION: This study showed that abnormal alterations in the structure and function of the left superior frontal gyrus and the corpus callosum may be the key brain regions involved in the pathogenesis of ADHD in patients and may be employed as an imaging metric for patients with ADHD pending future research. In addition, this meta-analysis discovered neuroanatomical or functional abnormalities in other brain regions in patients with ADHD as well as findings that can be utilized to guide future research.
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spelling pubmed-98535322023-01-21 Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder Yu, Miaomiao Gao, Xinyu Niu, Xiaoyu Zhang, Mengzhe Yang, Zhengui Han, Shaoqiang Cheng, Jingliang Zhang, Yong Front Psychiatry Psychiatry BACKGROUND: A large and growing body of neuroimaging research has concentrated on patients with attention-deficit/hyperactivity disorder (ADHD), but with inconsistent conclusions. This article was intended to investigate the common and certain neural alterations in the structure and function of the brain in patients with ADHD and further explore the differences in brain alterations between adults and children with ADHD. METHODS: We conducted an extensive literature search of whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies associated with ADHD. Two separate meta-analyses with the seed-based d mapping software package for functional neural activation and gray matter volume (GMV) were carried out, followed by a joint analysis and a subgroup analysis. RESULTS: This analysis included 29 VBM studies and 36 fMRI studies. Structurally, VBM analysis showed that the largest GMV diminutions in patients with ADHD were in several frontal-parietal brain regions, the limbic system, and the corpus callosum. Functionally, fMRI analysis discovered significant hypoactivation in several frontal-temporal brain regions, the right postcentral gyrus, the left insula, and the corpus callosum. CONCLUSION: This study showed that abnormal alterations in the structure and function of the left superior frontal gyrus and the corpus callosum may be the key brain regions involved in the pathogenesis of ADHD in patients and may be employed as an imaging metric for patients with ADHD pending future research. In addition, this meta-analysis discovered neuroanatomical or functional abnormalities in other brain regions in patients with ADHD as well as findings that can be utilized to guide future research. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853532/ /pubmed/36683981 http://dx.doi.org/10.3389/fpsyt.2022.1070142 Text en Copyright © 2023 Yu, Gao, Niu, Zhang, Yang, Han, Cheng and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Yu, Miaomiao
Gao, Xinyu
Niu, Xiaoyu
Zhang, Mengzhe
Yang, Zhengui
Han, Shaoqiang
Cheng, Jingliang
Zhang, Yong
Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title_full Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title_fullStr Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title_full_unstemmed Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title_short Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
title_sort meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853532/
https://www.ncbi.nlm.nih.gov/pubmed/36683981
http://dx.doi.org/10.3389/fpsyt.2022.1070142
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