The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

[Image: see text] Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against Mycobacte...

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Autores principales: Koller, Timm O., Scheid, Ullrich, Kösel, Teresa, Herrmann, Jennifer, Krug, Daniel, Boshoff, Helena I. M., Beckert, Bertrand, Evans, Joanna C., Schlemmer, Jan, Sloan, Becky, Weiner, Danielle M., Via, Laura E., Moosa, Atica, Ioerger, Thomas R., Graf, Michael, Zinshteyn, Boris, Abdelshahid, Maha, Nguyen, Fabian, Arenz, Stefan, Gille, Franziska, Siebke, Maik, Seedorf, Tim, Plettenburg, Oliver, Green, Rachel, Warnke, Anna-Luisa, Ullrich, Joachim, Warrass, Ralf, Barry, Clifton E., Warner, Digby F., Mizrahi, Valerie, Kirschning, Andreas, Wilson, Daniel N., Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853869/
https://www.ncbi.nlm.nih.gov/pubmed/36603206
http://dx.doi.org/10.1021/jacs.2c08816

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