Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

The emergence of treatment resistance significantly reduces the clinical utility of many effective targeted therapies. Although both genetic and epigenetic mechanisms of drug resistance have been reported, whether these mechanisms are stochastically selected in individual tumors or governed by a pre...

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Detalles Bibliográficos
Autores principales: George, Joshy, Chen, Yaohui, Abdelfattah, Nourhan, Yamamoto, Keiko, Gallup, Thomas D., Adamson, Scott I., Rybinski, Brad, Srivastava, Anuj, Kumar, Parveen, Lee, Min Gyu, Baskin, David S., Jiang, Wen, Choi, Jong Min, Flavahan, William, Chuang, Jeffrey H., Kim, Betty Y.S., Xu, Jiaqiong, Jung, Sung Yun, Yun, Kyuson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853917/
https://www.ncbi.nlm.nih.gov/pubmed/36688010
http://dx.doi.org/10.1158/2767-9764.CRC-22-0124

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