Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS

The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show...

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Detalles Bibliográficos
Autores principales: Yamagaki, Tohru, Osawa, Tsukiho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Mass Spectrometry Society of Japan 2022
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853952/
https://www.ncbi.nlm.nih.gov/pubmed/36713806
http://dx.doi.org/10.5702/massspectrometry.A0109
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author Yamagaki, Tohru
Osawa, Tsukiho
author_facet Yamagaki, Tohru
Osawa, Tsukiho
author_sort Yamagaki, Tohru
collection PubMed
description The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes due to the low absorbance efficiency. These properties of DAAQ are advantageous for the DAAQ-MALDI-MS analysis of alkaloids.
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spelling pubmed-98539522023-01-26 Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS Yamagaki, Tohru Osawa, Tsukiho Mass Spectrom (Tokyo) Technical Report The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes due to the low absorbance efficiency. These properties of DAAQ are advantageous for the DAAQ-MALDI-MS analysis of alkaloids. The Mass Spectrometry Society of Japan 2022 2022-12-28 /pmc/articles/PMC9853952/ /pubmed/36713806 http://dx.doi.org/10.5702/massspectrometry.A0109 Text en Copyright © 2022 Tohru Yamagaki and Tsukiho Osawa. https://creativecommons.org/licenses/by/2.5/This is an open-access article distributed under the terms of Creative Commons Attribution Non-Commercial 4.0 International License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Technical Report
Yamagaki, Tohru
Osawa, Tsukiho
Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title_full Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title_fullStr Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title_full_unstemmed Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title_short Diaminoanthraquinone Enhances Alkaloid Ionization in MALDI-MS
title_sort diaminoanthraquinone enhances alkaloid ionization in maldi-ms
topic Technical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853952/
https://www.ncbi.nlm.nih.gov/pubmed/36713806
http://dx.doi.org/10.5702/massspectrometry.A0109
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