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Age and APOE affect L-carnitine system metabolites in the brain in the APOE-TR model

With age the apolipoprotein E (APOE) E4 allele (involved in lipid homeostasis) is associated with perturbation of bioenergetics pathways in Alzheimer’s disease (AD). We therefore hypothesized that in aging mice APOE genotype would affect the L-carnitine system (central to lipid bioenergetics), in th...

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Detalles Bibliográficos
Autores principales:	Huguenard, Claire J. C., Cseresznye, Adam, Darcey, Teresa, Nkiliza, Aurore, Evans, James E., Hazen, Stanley L., Mullan, Michael, Crawford, Fiona, Abdullah, Laila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853982/ https://www.ncbi.nlm.nih.gov/pubmed/36688151 http://dx.doi.org/10.3389/fnagi.2022.1059017

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