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A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread

BACKGROUND: Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it difficult to develop treatment recommendations. This study aims to analyze the clini...

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Autores principales: Imaizumi, Jun, Moritani, Konosuke, Takamizawa, Yasuyuki, Inoue, Manabu, Tsukamoto, Shunsuke, Kanemitsu, Yukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854029/
https://www.ncbi.nlm.nih.gov/pubmed/36658590
http://dx.doi.org/10.1186/s12957-022-02872-z
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author Imaizumi, Jun
Moritani, Konosuke
Takamizawa, Yasuyuki
Inoue, Manabu
Tsukamoto, Shunsuke
Kanemitsu, Yukihide
author_facet Imaizumi, Jun
Moritani, Konosuke
Takamizawa, Yasuyuki
Inoue, Manabu
Tsukamoto, Shunsuke
Kanemitsu, Yukihide
author_sort Imaizumi, Jun
collection PubMed
description BACKGROUND: Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it difficult to develop treatment recommendations. This study aims to analyze the clinical and pathological features of perianal Paget’s disease (PPD) and to explore rational treatment options and follow-up for this disease. METHODS: The National Cancer Center Hospital database was searched for all cases of perianal Paget’s disease diagnosed between 2006 and 2021. In the 14 patients identified, we reviewed the diagnosis, management, and outcomes of adenocarcinoma with pagetoid spread, including suspected or recurrent cases. RESULTS: All 14 cases met the inclusion criteria. The median follow-up period after diagnosis was 4.5 (range, 0.1–13.0) years. Pagetoid spread before initial treatment was suspected in 12 cases (85.7%). Underlying rectal cancer was identified in 6 cases, and no primary tumor was detected in the other 6 cases. Seven patients had recurrent disease, with the median time to recurrence of 34.6 (range, 19.2–81.7) months. The time to the first relapse was 3 months, and that to the second relapse was 6 months. The overall 5-year survival rate was 90.0%. CONCLUSIONS: Endoscopic and radiologic evaluation, as well as immunohistologic examination, should be performed. is to differentiate PPD with and without underlying anorectal carcinoma. The time to first recurrence varies widely, and long-term and regular follow-up for more than 5 years is considered necessary for local recurrence and distant metastasis.
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spelling pubmed-98540292023-01-21 A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread Imaizumi, Jun Moritani, Konosuke Takamizawa, Yasuyuki Inoue, Manabu Tsukamoto, Shunsuke Kanemitsu, Yukihide World J Surg Oncol Research BACKGROUND: Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it difficult to develop treatment recommendations. This study aims to analyze the clinical and pathological features of perianal Paget’s disease (PPD) and to explore rational treatment options and follow-up for this disease. METHODS: The National Cancer Center Hospital database was searched for all cases of perianal Paget’s disease diagnosed between 2006 and 2021. In the 14 patients identified, we reviewed the diagnosis, management, and outcomes of adenocarcinoma with pagetoid spread, including suspected or recurrent cases. RESULTS: All 14 cases met the inclusion criteria. The median follow-up period after diagnosis was 4.5 (range, 0.1–13.0) years. Pagetoid spread before initial treatment was suspected in 12 cases (85.7%). Underlying rectal cancer was identified in 6 cases, and no primary tumor was detected in the other 6 cases. Seven patients had recurrent disease, with the median time to recurrence of 34.6 (range, 19.2–81.7) months. The time to the first relapse was 3 months, and that to the second relapse was 6 months. The overall 5-year survival rate was 90.0%. CONCLUSIONS: Endoscopic and radiologic evaluation, as well as immunohistologic examination, should be performed. is to differentiate PPD with and without underlying anorectal carcinoma. The time to first recurrence varies widely, and long-term and regular follow-up for more than 5 years is considered necessary for local recurrence and distant metastasis. BioMed Central 2023-01-20 /pmc/articles/PMC9854029/ /pubmed/36658590 http://dx.doi.org/10.1186/s12957-022-02872-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Imaizumi, Jun
Moritani, Konosuke
Takamizawa, Yasuyuki
Inoue, Manabu
Tsukamoto, Shunsuke
Kanemitsu, Yukihide
A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title_full A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title_fullStr A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title_full_unstemmed A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title_short A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread
title_sort review of 14 cases of perianal paget’s disease: characteristics of anorectal cancer with pagetoid spread
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854029/
https://www.ncbi.nlm.nih.gov/pubmed/36658590
http://dx.doi.org/10.1186/s12957-022-02872-z
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