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Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress

BACKGROUND: The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer’s disease (AD). Thus, improving BMEC function may be beneficial for AD treatment. Tanshinone IIA (Tan IIA) has been proved to am...

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Detalles Bibliográficos
Autores principales:	Wan, Can, Liu, Xiao-Qi, Chen, Mei, Ma, Hui-Han, Wu, Guang-Liang, Qiao, Li-Jun, Cai, Ye-Feng, Zhang, Shi-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854034/ https://www.ncbi.nlm.nih.gov/pubmed/36670462 http://dx.doi.org/10.1186/s12967-023-03889-y

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