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Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components?
BACKGROUND AND OBJECTIVES: Pheochromocytoma and adrenal adenoma are common space-occupying lesions of the adrenal gland, and incorrect surgery may lead to adrenal crisis. We used a new method, dual-energy spectral detector computed tomography (SDCT), to differentiate between the two. MATERIALS AND M...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854128/ https://www.ncbi.nlm.nih.gov/pubmed/36686431 http://dx.doi.org/10.3389/fendo.2022.998154 |
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author | Wang, Yu-li Liu, Xiao-lei Liao, Ze-bing Lu, Xiao-mei Chen, Ling-lin Lei, Yi Zhang, Han-wen Lin, Fan |
author_facet | Wang, Yu-li Liu, Xiao-lei Liao, Ze-bing Lu, Xiao-mei Chen, Ling-lin Lei, Yi Zhang, Han-wen Lin, Fan |
author_sort | Wang, Yu-li |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Pheochromocytoma and adrenal adenoma are common space-occupying lesions of the adrenal gland, and incorrect surgery may lead to adrenal crisis. We used a new method, dual-energy spectral detector computed tomography (SDCT), to differentiate between the two. MATERIALS AND METHODS: We analysed the imaging images of patients with SDCT scans and pathologically confirmed adrenal adenomas (n=70) and pheochromocytomas (n=15). The 40, 70, and 100 KeV virtual monoenergetic images (VMIs) were reconstructed based on the SCDT arterial phase, and the correlation between the arterial/venous phase iodine concentration (AP-IC/VP-IC), the effective atomic number (Z-effect), the slope of the Hounsfield unit attenuation plot (VMI slope) and the pathological results was tested. The Shapiro−Wilk test was used to determine whether the above data conformed to a normal distribution. For parameters with P greater than 0.05, Student’s t test was used, and the Mann−Whitney test was used for the remaining parameters. A ROC curve was drawn based on the results. RESULTS: Student’s t test showed that the 40 KeV VMI and the VMI slope were both statistically significant (P<0.01). The Mann−Whitney U test showed that ID-A was statistically significant (P=0.004). ROC curve analysis showed that 40 keV VMI (AUC=0.818), AP-IC (AUC=0.736), difference (AUC=0.817) and VMI-Slope (0.817) could be used to differentiate adrenal adenoma from pheochromocytoma. CONCLUSION: The effect of lipid components on SDCT parameters can be used to differentiate adrenal adenoma from pheochromocytoma. |
format | Online Article Text |
id | pubmed-9854128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98541282023-01-21 Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? Wang, Yu-li Liu, Xiao-lei Liao, Ze-bing Lu, Xiao-mei Chen, Ling-lin Lei, Yi Zhang, Han-wen Lin, Fan Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND OBJECTIVES: Pheochromocytoma and adrenal adenoma are common space-occupying lesions of the adrenal gland, and incorrect surgery may lead to adrenal crisis. We used a new method, dual-energy spectral detector computed tomography (SDCT), to differentiate between the two. MATERIALS AND METHODS: We analysed the imaging images of patients with SDCT scans and pathologically confirmed adrenal adenomas (n=70) and pheochromocytomas (n=15). The 40, 70, and 100 KeV virtual monoenergetic images (VMIs) were reconstructed based on the SCDT arterial phase, and the correlation between the arterial/venous phase iodine concentration (AP-IC/VP-IC), the effective atomic number (Z-effect), the slope of the Hounsfield unit attenuation plot (VMI slope) and the pathological results was tested. The Shapiro−Wilk test was used to determine whether the above data conformed to a normal distribution. For parameters with P greater than 0.05, Student’s t test was used, and the Mann−Whitney test was used for the remaining parameters. A ROC curve was drawn based on the results. RESULTS: Student’s t test showed that the 40 KeV VMI and the VMI slope were both statistically significant (P<0.01). The Mann−Whitney U test showed that ID-A was statistically significant (P=0.004). ROC curve analysis showed that 40 keV VMI (AUC=0.818), AP-IC (AUC=0.736), difference (AUC=0.817) and VMI-Slope (0.817) could be used to differentiate adrenal adenoma from pheochromocytoma. CONCLUSION: The effect of lipid components on SDCT parameters can be used to differentiate adrenal adenoma from pheochromocytoma. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9854128/ /pubmed/36686431 http://dx.doi.org/10.3389/fendo.2022.998154 Text en Copyright © 2023 Wang, Liu, Liao, Lu, Chen, Lei, Zhang and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Wang, Yu-li Liu, Xiao-lei Liao, Ze-bing Lu, Xiao-mei Chen, Ling-lin Lei, Yi Zhang, Han-wen Lin, Fan Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title | Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title_full | Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title_fullStr | Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title_full_unstemmed | Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title_short | Dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: Changes in the energy level curve, a phenomenon caused by lipid components? |
title_sort | dual-energy spectral detector computed tomography differential diagnosis of adrenal adenoma and pheochromocytoma: changes in the energy level curve, a phenomenon caused by lipid components? |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854128/ https://www.ncbi.nlm.nih.gov/pubmed/36686431 http://dx.doi.org/10.3389/fendo.2022.998154 |
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