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The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis
BACKGROUND: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854153/ https://www.ncbi.nlm.nih.gov/pubmed/36658564 http://dx.doi.org/10.1186/s12957-023-02901-5 |
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author | Dai, Yu-Shi Hu, Hai-Jie Lv, Tian-run Hu, Ya-Fei Zou, Rui-Qi Li, Fu-Yu |
author_facet | Dai, Yu-Shi Hu, Hai-Jie Lv, Tian-run Hu, Ya-Fei Zou, Rui-Qi Li, Fu-Yu |
author_sort | Dai, Yu-Shi |
collection | PubMed |
description | BACKGROUND: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial. METHOD: The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection. Odds ratios (ORs) with 95% confidence intervals were used to determine the effect size. RESULT: A total of 11 articles were included in this meta-analysis, including 3007 patients. The narrow group had significantly lower 1-, 3-, and 5-year overall survival rates and recurrence-free survival rates than the wide group. Postoperative morbidity and prognostic factors were also evaluated. CONCLUSION: A resection margin width of over 10 mm is recommended in intrahepatic cholangiocarcinoma patients, especially in patients with negative lymph node and early tumor stage. When the resection margin width cannot be greater than 10 mm, we should ensure that the resection margin width is greater than 5 mm. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02901-5. |
format | Online Article Text |
id | pubmed-9854153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98541532023-01-21 The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis Dai, Yu-Shi Hu, Hai-Jie Lv, Tian-run Hu, Ya-Fei Zou, Rui-Qi Li, Fu-Yu World J Surg Oncol Review BACKGROUND: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial. METHOD: The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection. Odds ratios (ORs) with 95% confidence intervals were used to determine the effect size. RESULT: A total of 11 articles were included in this meta-analysis, including 3007 patients. The narrow group had significantly lower 1-, 3-, and 5-year overall survival rates and recurrence-free survival rates than the wide group. Postoperative morbidity and prognostic factors were also evaluated. CONCLUSION: A resection margin width of over 10 mm is recommended in intrahepatic cholangiocarcinoma patients, especially in patients with negative lymph node and early tumor stage. When the resection margin width cannot be greater than 10 mm, we should ensure that the resection margin width is greater than 5 mm. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-023-02901-5. BioMed Central 2023-01-20 /pmc/articles/PMC9854153/ /pubmed/36658564 http://dx.doi.org/10.1186/s12957-023-02901-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Dai, Yu-Shi Hu, Hai-Jie Lv, Tian-run Hu, Ya-Fei Zou, Rui-Qi Li, Fu-Yu The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title | The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title_full | The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title_fullStr | The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title_full_unstemmed | The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title_short | The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
title_sort | influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854153/ https://www.ncbi.nlm.nih.gov/pubmed/36658564 http://dx.doi.org/10.1186/s12957-023-02901-5 |
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