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A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells

BACKGROUND: Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancies. Mcl-1, another anti-apoptotic Bcl-2 family member, is recognized as the prim...

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Detalles Bibliográficos
Autores principales:	Zhao, Tianming, He, Qiang, Xie, Shurong, Zhan, Huien, Jiang, Cheng, Lin, Shengbin, Liu, Fangshu, Wang, Cong, Chen, Guo, Zeng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854187/ https://www.ncbi.nlm.nih.gov/pubmed/36658493 http://dx.doi.org/10.1186/s10020-022-00565-7

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