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Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854440/ https://www.ncbi.nlm.nih.gov/pubmed/36671009 http://dx.doi.org/10.3390/antiox12010147 |
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author | Serreli, Gabriele Deiana, Monica |
author_facet | Serreli, Gabriele Deiana, Monica |
author_sort | Serreli, Gabriele |
collection | PubMed |
description | Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and neuronal nitric oxide synthase (nNOS). The expression and activity of these isoforms depends on the activation/deactivation of different signaling pathways at an intracellular level following different physiological and pathological stimuli. Compounds of natural origin such as polyphenols, which are obtainable through diet, have been widely studied in recent years in in vivo and in vitro investigations for their ability to induce or inhibit NO release, depending on the tissue. In this review, we aim to disclose the scientific evidence relating to the activity of the main dietary polyphenols in the modulation of the intracellular pathways involved in the expression and/or functionality of the NOS isoforms. |
format | Online Article Text |
id | pubmed-9854440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98544402023-01-21 Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review Serreli, Gabriele Deiana, Monica Antioxidants (Basel) Review Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and neuronal nitric oxide synthase (nNOS). The expression and activity of these isoforms depends on the activation/deactivation of different signaling pathways at an intracellular level following different physiological and pathological stimuli. Compounds of natural origin such as polyphenols, which are obtainable through diet, have been widely studied in recent years in in vivo and in vitro investigations for their ability to induce or inhibit NO release, depending on the tissue. In this review, we aim to disclose the scientific evidence relating to the activity of the main dietary polyphenols in the modulation of the intracellular pathways involved in the expression and/or functionality of the NOS isoforms. MDPI 2023-01-07 /pmc/articles/PMC9854440/ /pubmed/36671009 http://dx.doi.org/10.3390/antiox12010147 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Serreli, Gabriele Deiana, Monica Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title_full | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title_fullStr | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title_full_unstemmed | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title_short | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
title_sort | role of dietary polyphenols in the activity and expression of nitric oxide synthases: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854440/ https://www.ncbi.nlm.nih.gov/pubmed/36671009 http://dx.doi.org/10.3390/antiox12010147 |
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