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Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis

Appropriate postoperative antibiotic treatment in patients with infective endocarditis (IE) reduces the risks of recurrence and mortality. However, concerns about adverse drug reactions arise due to prolonged antibiotic usage. Therefore, we compared the recurrence and mortality rates according to th...

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Autores principales: Kim, Jinnam, Kim, Jung Ho, Lee, Hi Jae, Lee, Se Ju, Kim, Changhyup, Lee, Jung Ah, Lee, Ki Hyun, Pyo, Won Kyung, Ahn, Jin Young, Jeong, Su Jin, Ku, Nam Su, Lee, Seung Hyun, Choi, Jun Yong, Yeom, Joon-Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854446/
https://www.ncbi.nlm.nih.gov/pubmed/36671376
http://dx.doi.org/10.3390/antibiotics12010173
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author Kim, Jinnam
Kim, Jung Ho
Lee, Hi Jae
Lee, Se Ju
Kim, Changhyup
Lee, Jung Ah
Lee, Ki Hyun
Pyo, Won Kyung
Ahn, Jin Young
Jeong, Su Jin
Ku, Nam Su
Lee, Seung Hyun
Choi, Jun Yong
Yeom, Joon-Sup
author_facet Kim, Jinnam
Kim, Jung Ho
Lee, Hi Jae
Lee, Se Ju
Kim, Changhyup
Lee, Jung Ah
Lee, Ki Hyun
Pyo, Won Kyung
Ahn, Jin Young
Jeong, Su Jin
Ku, Nam Su
Lee, Seung Hyun
Choi, Jun Yong
Yeom, Joon-Sup
author_sort Kim, Jinnam
collection PubMed
description Appropriate postoperative antibiotic treatment in patients with infective endocarditis (IE) reduces the risks of recurrence and mortality. However, concerns about adverse drug reactions arise due to prolonged antibiotic usage. Therefore, we compared the recurrence and mortality rates according to the duration of postoperative antibiotic therapy in patients with IE. From 2005 to 2017, we retrospectively reviewed 416 patients with IE treated at a tertiary hospital in South Korea; among these, 216 patients who underwent heart valve surgery and received appropriate antibiotics were enrolled. The patients were divided into two groups based on the duration of usage of postoperative antibiotic therapy; the duration of postoperative antibiotic therapy was more than two weeks in 156 patients (72.2%) and two weeks or less in 60 patients (27.8%). The primary endpoint was IE relapse. The secondary endpoints were 1-year IE recurrence, 1-year mortality, and postoperative complication rates. The median age was 53 (interquartile range: 38–62) years. The relapse rate of IE was 0.9% (2/216). There was no statistical difference in relapse (0.0% vs. 1.3%, p = 0.379), 1-year recurrence (1.7% vs. 1.3%, p = 0.829), or 1-year mortality (10.0% vs. 5.8%, p = 0.274) between patients with postoperative antibiotic administration of two weeks or less versus more than two weeks. The duration of postoperative antibiotic therapy did not affect the 1-year mortality rate (log-rank test, p = 0.393). In conclusion, there was no statistically significant difference in recurrence, mortality, or postoperative complications according to the duration of postoperative antibiotic therapy.
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spelling pubmed-98544462023-01-21 Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis Kim, Jinnam Kim, Jung Ho Lee, Hi Jae Lee, Se Ju Kim, Changhyup Lee, Jung Ah Lee, Ki Hyun Pyo, Won Kyung Ahn, Jin Young Jeong, Su Jin Ku, Nam Su Lee, Seung Hyun Choi, Jun Yong Yeom, Joon-Sup Antibiotics (Basel) Article Appropriate postoperative antibiotic treatment in patients with infective endocarditis (IE) reduces the risks of recurrence and mortality. However, concerns about adverse drug reactions arise due to prolonged antibiotic usage. Therefore, we compared the recurrence and mortality rates according to the duration of postoperative antibiotic therapy in patients with IE. From 2005 to 2017, we retrospectively reviewed 416 patients with IE treated at a tertiary hospital in South Korea; among these, 216 patients who underwent heart valve surgery and received appropriate antibiotics were enrolled. The patients were divided into two groups based on the duration of usage of postoperative antibiotic therapy; the duration of postoperative antibiotic therapy was more than two weeks in 156 patients (72.2%) and two weeks or less in 60 patients (27.8%). The primary endpoint was IE relapse. The secondary endpoints were 1-year IE recurrence, 1-year mortality, and postoperative complication rates. The median age was 53 (interquartile range: 38–62) years. The relapse rate of IE was 0.9% (2/216). There was no statistical difference in relapse (0.0% vs. 1.3%, p = 0.379), 1-year recurrence (1.7% vs. 1.3%, p = 0.829), or 1-year mortality (10.0% vs. 5.8%, p = 0.274) between patients with postoperative antibiotic administration of two weeks or less versus more than two weeks. The duration of postoperative antibiotic therapy did not affect the 1-year mortality rate (log-rank test, p = 0.393). In conclusion, there was no statistically significant difference in recurrence, mortality, or postoperative complications according to the duration of postoperative antibiotic therapy. MDPI 2023-01-15 /pmc/articles/PMC9854446/ /pubmed/36671376 http://dx.doi.org/10.3390/antibiotics12010173 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Jinnam
Kim, Jung Ho
Lee, Hi Jae
Lee, Se Ju
Kim, Changhyup
Lee, Jung Ah
Lee, Ki Hyun
Pyo, Won Kyung
Ahn, Jin Young
Jeong, Su Jin
Ku, Nam Su
Lee, Seung Hyun
Choi, Jun Yong
Yeom, Joon-Sup
Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title_full Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title_fullStr Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title_full_unstemmed Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title_short Impact of the Duration of Postoperative Antibiotics on the Prognosis of Patients with Infective Endocarditis
title_sort impact of the duration of postoperative antibiotics on the prognosis of patients with infective endocarditis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854446/
https://www.ncbi.nlm.nih.gov/pubmed/36671376
http://dx.doi.org/10.3390/antibiotics12010173
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