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Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic

Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial...

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Autores principales: Spernovasilis, Nikolaos, Kritsotakis, Evangelos I., Mathioudaki, Anna, Vouidaski, Alexandra, Markaki, Ioulia, Psaroudaki, Despoina, Ioannou, Petros, Kofteridis, Diamantis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854477/
https://www.ncbi.nlm.nih.gov/pubmed/36671240
http://dx.doi.org/10.3390/antibiotics12010039
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author Spernovasilis, Nikolaos
Kritsotakis, Evangelos I.
Mathioudaki, Anna
Vouidaski, Alexandra
Markaki, Ioulia
Psaroudaki, Despoina
Ioannou, Petros
Kofteridis, Diamantis P.
author_facet Spernovasilis, Nikolaos
Kritsotakis, Evangelos I.
Mathioudaki, Anna
Vouidaski, Alexandra
Markaki, Ioulia
Psaroudaki, Despoina
Ioannou, Petros
Kofteridis, Diamantis P.
author_sort Spernovasilis, Nikolaos
collection PubMed
description Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial use and quality of antimicrobial prescribing during the COVID-19 pandemic. Methods: All adult inpatients in the University Hospital of Heraklion in Greece were audited twice, before and after the implementation of the ASP, in October 2019 and October 2020, respectively. Patient characteristics, indications and diagnoses for antimicrobial administration, antimicrobials prescribed, and compliance with treatment guidelines were recorded. Results: Of 743 adult inpatients on the days of the two surveys, 398 (53.6%) were on antimicrobials for 437 diagnoses. Following implementation of the ASP, there was substantial decrease in the utilization of carbapenems (4.9% of all antibacterials prescribed in the second PPS compared to 10.3% in the first PPS). A significant improvement was observed for all indicators of the quality of antimicrobial prescribing. Conclusions: Our study demonstrated a positive impact of an ASP implementation during the first stages of the COVID-19 pandemic on reducing the use of last-line antimicrobials and improving overall quality of antimicrobial prescribing.
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spelling pubmed-98544772023-01-21 Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic Spernovasilis, Nikolaos Kritsotakis, Evangelos I. Mathioudaki, Anna Vouidaski, Alexandra Markaki, Ioulia Psaroudaki, Despoina Ioannou, Petros Kofteridis, Diamantis P. Antibiotics (Basel) Article Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial use and quality of antimicrobial prescribing during the COVID-19 pandemic. Methods: All adult inpatients in the University Hospital of Heraklion in Greece were audited twice, before and after the implementation of the ASP, in October 2019 and October 2020, respectively. Patient characteristics, indications and diagnoses for antimicrobial administration, antimicrobials prescribed, and compliance with treatment guidelines were recorded. Results: Of 743 adult inpatients on the days of the two surveys, 398 (53.6%) were on antimicrobials for 437 diagnoses. Following implementation of the ASP, there was substantial decrease in the utilization of carbapenems (4.9% of all antibacterials prescribed in the second PPS compared to 10.3% in the first PPS). A significant improvement was observed for all indicators of the quality of antimicrobial prescribing. Conclusions: Our study demonstrated a positive impact of an ASP implementation during the first stages of the COVID-19 pandemic on reducing the use of last-line antimicrobials and improving overall quality of antimicrobial prescribing. MDPI 2022-12-27 /pmc/articles/PMC9854477/ /pubmed/36671240 http://dx.doi.org/10.3390/antibiotics12010039 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spernovasilis, Nikolaos
Kritsotakis, Evangelos I.
Mathioudaki, Anna
Vouidaski, Alexandra
Markaki, Ioulia
Psaroudaki, Despoina
Ioannou, Petros
Kofteridis, Diamantis P.
Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title_full Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title_fullStr Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title_full_unstemmed Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title_short Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic
title_sort antimicrobial prescribing before and after the implementation of a carbapenem-focused antimicrobial stewardship program in a greek tertiary hospital during the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854477/
https://www.ncbi.nlm.nih.gov/pubmed/36671240
http://dx.doi.org/10.3390/antibiotics12010039
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