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Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge

For decades, the potential role of probiotics in the prevention and treatment of recurrent urinary tract infections has been extensively studied. However, achieving an effective problem-solving strategy has thus far proven elusive. Perhaps adopting a military paradigm might expedite our assault on c...

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Detalles Bibliográficos
Autor principal: Watson, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854529/
https://www.ncbi.nlm.nih.gov/pubmed/36671368
http://dx.doi.org/10.3390/antibiotics12010167
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author Watson, Richard A.
author_facet Watson, Richard A.
author_sort Watson, Richard A.
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description For decades, the potential role of probiotics in the prevention and treatment of recurrent urinary tract infections has been extensively studied. However, achieving an effective problem-solving strategy has thus far proven elusive. Perhaps adopting a military paradigm might expedite our assault on chronic, recurring bacteriuria in women. What is needed is a targeted strategy with specific attention to (1) the enemy: the case-specific uropathogen; (2) the battlefield: the extraordinarily complex interplay of factors within the bladder, unique to a given patient, which interface with profoundly important influences from the gut biome, as well as the vaginal biota; (3) the weapon: an antimicrobial probiotic with demonstrated activity against that specific uropathogen; (4) a new strategy: taking these complexities into account, we posit a key role for the instillation of case-specific lactobacilli directly into the bladder of the designated patient. This newly proposed, targeted intervention might be termed “Probiotic Intravesical Organic Therapy—PIVOT”; and (5) the long campaign: reaching clinically proven success may entail a long campaign. However, already, on many fronts, the elements necessary for victory recently seem to be falling into place.
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spelling pubmed-98545292023-01-21 Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge Watson, Richard A. Antibiotics (Basel) Perspective For decades, the potential role of probiotics in the prevention and treatment of recurrent urinary tract infections has been extensively studied. However, achieving an effective problem-solving strategy has thus far proven elusive. Perhaps adopting a military paradigm might expedite our assault on chronic, recurring bacteriuria in women. What is needed is a targeted strategy with specific attention to (1) the enemy: the case-specific uropathogen; (2) the battlefield: the extraordinarily complex interplay of factors within the bladder, unique to a given patient, which interface with profoundly important influences from the gut biome, as well as the vaginal biota; (3) the weapon: an antimicrobial probiotic with demonstrated activity against that specific uropathogen; (4) a new strategy: taking these complexities into account, we posit a key role for the instillation of case-specific lactobacilli directly into the bladder of the designated patient. This newly proposed, targeted intervention might be termed “Probiotic Intravesical Organic Therapy—PIVOT”; and (5) the long campaign: reaching clinically proven success may entail a long campaign. However, already, on many fronts, the elements necessary for victory recently seem to be falling into place. MDPI 2023-01-13 /pmc/articles/PMC9854529/ /pubmed/36671368 http://dx.doi.org/10.3390/antibiotics12010167 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Watson, Richard A.
Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title_full Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title_fullStr Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title_full_unstemmed Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title_short Enlisting Probiotics to Combat Recurrent Urinary Tract Infections in Women—A Military Strategy for Meeting the Challenge
title_sort enlisting probiotics to combat recurrent urinary tract infections in women—a military strategy for meeting the challenge
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854529/
https://www.ncbi.nlm.nih.gov/pubmed/36671368
http://dx.doi.org/10.3390/antibiotics12010167
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