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Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies

Reprogrammed metabolism is regarded as a hallmark of cancer and offers a selective advantage to tumor cells during carcinogenesis. The redox equilibrium is necessary for growth, spread and the antioxidant pathways are boosted following Reactive Oxygen Species (ROS) production to prevent cell damage...

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Autores principales: Gothland, Adélie, Jary, Aude, Grange, Philippe, Leducq, Valentin, Beauvais-Remigereau, Laurianne, Dupin, Nicolas, Marcelin, Anne-Geneviève, Calvez, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854560/
https://www.ncbi.nlm.nih.gov/pubmed/36670946
http://dx.doi.org/10.3390/antiox12010084
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author Gothland, Adélie
Jary, Aude
Grange, Philippe
Leducq, Valentin
Beauvais-Remigereau, Laurianne
Dupin, Nicolas
Marcelin, Anne-Geneviève
Calvez, Vincent
author_facet Gothland, Adélie
Jary, Aude
Grange, Philippe
Leducq, Valentin
Beauvais-Remigereau, Laurianne
Dupin, Nicolas
Marcelin, Anne-Geneviève
Calvez, Vincent
author_sort Gothland, Adélie
collection PubMed
description Reprogrammed metabolism is regarded as a hallmark of cancer and offers a selective advantage to tumor cells during carcinogenesis. The redox equilibrium is necessary for growth, spread and the antioxidant pathways are boosted following Reactive Oxygen Species (ROS) production to prevent cell damage in tumor cells. Human herpesvirus 8 (HHV-8), the etiologic agent of Kaposi sarcoma KS and primary effusion lymphoma (PEL), is an oncogenic virus that disrupts cell survival-related molecular signaling pathways leading to immune host evasion, cells growths, angiogenesis and inflammatory tumor-environment. We recently reported that primaquine diphosphate causes cell death by apoptosis in HHV-8 infected PEL cell lines in vivo and exhibits therapeutic anti-tumor activity in mice models and advanced KS. Our findings also suggest that the primaquine-induced apoptosis in PEL cells is mostly influenced by ROS production and targeting the redox balance could be a new approach to treat HHV-8 related diseases. In this review, we summarized the knowledge about the influence of ROS in cancer development; more specifically, the proof of evidence from our work and from the literature that redox pathways are important for the development of HHV-8 pathologies.
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spelling pubmed-98545602023-01-21 Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies Gothland, Adélie Jary, Aude Grange, Philippe Leducq, Valentin Beauvais-Remigereau, Laurianne Dupin, Nicolas Marcelin, Anne-Geneviève Calvez, Vincent Antioxidants (Basel) Review Reprogrammed metabolism is regarded as a hallmark of cancer and offers a selective advantage to tumor cells during carcinogenesis. The redox equilibrium is necessary for growth, spread and the antioxidant pathways are boosted following Reactive Oxygen Species (ROS) production to prevent cell damage in tumor cells. Human herpesvirus 8 (HHV-8), the etiologic agent of Kaposi sarcoma KS and primary effusion lymphoma (PEL), is an oncogenic virus that disrupts cell survival-related molecular signaling pathways leading to immune host evasion, cells growths, angiogenesis and inflammatory tumor-environment. We recently reported that primaquine diphosphate causes cell death by apoptosis in HHV-8 infected PEL cell lines in vivo and exhibits therapeutic anti-tumor activity in mice models and advanced KS. Our findings also suggest that the primaquine-induced apoptosis in PEL cells is mostly influenced by ROS production and targeting the redox balance could be a new approach to treat HHV-8 related diseases. In this review, we summarized the knowledge about the influence of ROS in cancer development; more specifically, the proof of evidence from our work and from the literature that redox pathways are important for the development of HHV-8 pathologies. MDPI 2022-12-30 /pmc/articles/PMC9854560/ /pubmed/36670946 http://dx.doi.org/10.3390/antiox12010084 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gothland, Adélie
Jary, Aude
Grange, Philippe
Leducq, Valentin
Beauvais-Remigereau, Laurianne
Dupin, Nicolas
Marcelin, Anne-Geneviève
Calvez, Vincent
Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title_full Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title_fullStr Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title_full_unstemmed Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title_short Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies
title_sort harnessing redox disruption to treat human herpesvirus 8 (hhv-8) related malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854560/
https://www.ncbi.nlm.nih.gov/pubmed/36670946
http://dx.doi.org/10.3390/antiox12010084
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