Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant Escherichia coli, In Vitro and in a Murine Peritonitis Model

Colistin is a drug of last resort to treat extreme drug-resistant Enterobacterales, but is limited by dose-dependent toxicity and the emergence of resistance. A recently developed antimicrobial pseudopeptide, Pep16, which acts on the cell membrane, may be synergistic with colistin and limit the emer...

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Detalles Bibliográficos
Autores principales: Chosidow, Samuel, Fantin, Bruno, Nicolas, Irène, Mascary, Jean-Baptiste, Chau, Françoise, Bordeau, Valérie, Verdier, Marie-Clemence, Rocheteau, Pierre, Guérin, Francois, Cattoir, Vincent, de Lastours, Victoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854584/
https://www.ncbi.nlm.nih.gov/pubmed/36671282
http://dx.doi.org/10.3390/antibiotics12010081

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