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Engineering Advanced Drug Delivery Systems for Dry Eye: A Review
Dry eye disease (DED) is a widespread and frequently reported multifactorial ocular disease that not only causes ocular discomfort but also damages the cornea and conjunctiva. At present, topical administration is the most common treatment modality for DED. Due to the existence of multiple biologica...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854618/ https://www.ncbi.nlm.nih.gov/pubmed/36671625 http://dx.doi.org/10.3390/bioengineering10010053 |
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author | Wang, Tian-Zuo Liu, Xin-Xin Wang, Si-Yu Liu, Yan Pan, Xin-Yang Wang, Jing-Jie Nan, Kai-Hui |
author_facet | Wang, Tian-Zuo Liu, Xin-Xin Wang, Si-Yu Liu, Yan Pan, Xin-Yang Wang, Jing-Jie Nan, Kai-Hui |
author_sort | Wang, Tian-Zuo |
collection | PubMed |
description | Dry eye disease (DED) is a widespread and frequently reported multifactorial ocular disease that not only causes ocular discomfort but also damages the cornea and conjunctiva. At present, topical administration is the most common treatment modality for DED. Due to the existence of multiple biological barriers, instilled drugs generally exhibit short action times and poor penetration on the ocular surface. To resolve these issues, several advanced drug delivery systems have been proposed. This review discusses new dosage forms of drugs for the treatment of DED in terms of their characteristics and advantages. Innovative formulations that are currently available in the market and under clinical investigation are elaborated. Meanwhile, their deficiencies are discussed. It is envisioned that the flourishing of advanced drug delivery systems will lead to improved management of DED in the near future. |
format | Online Article Text |
id | pubmed-9854618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98546182023-01-21 Engineering Advanced Drug Delivery Systems for Dry Eye: A Review Wang, Tian-Zuo Liu, Xin-Xin Wang, Si-Yu Liu, Yan Pan, Xin-Yang Wang, Jing-Jie Nan, Kai-Hui Bioengineering (Basel) Review Dry eye disease (DED) is a widespread and frequently reported multifactorial ocular disease that not only causes ocular discomfort but also damages the cornea and conjunctiva. At present, topical administration is the most common treatment modality for DED. Due to the existence of multiple biological barriers, instilled drugs generally exhibit short action times and poor penetration on the ocular surface. To resolve these issues, several advanced drug delivery systems have been proposed. This review discusses new dosage forms of drugs for the treatment of DED in terms of their characteristics and advantages. Innovative formulations that are currently available in the market and under clinical investigation are elaborated. Meanwhile, their deficiencies are discussed. It is envisioned that the flourishing of advanced drug delivery systems will lead to improved management of DED in the near future. MDPI 2022-12-31 /pmc/articles/PMC9854618/ /pubmed/36671625 http://dx.doi.org/10.3390/bioengineering10010053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Tian-Zuo Liu, Xin-Xin Wang, Si-Yu Liu, Yan Pan, Xin-Yang Wang, Jing-Jie Nan, Kai-Hui Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title | Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title_full | Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title_fullStr | Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title_full_unstemmed | Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title_short | Engineering Advanced Drug Delivery Systems for Dry Eye: A Review |
title_sort | engineering advanced drug delivery systems for dry eye: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854618/ https://www.ncbi.nlm.nih.gov/pubmed/36671625 http://dx.doi.org/10.3390/bioengineering10010053 |
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