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The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress
In diseases with concomitant oxidative stress, chronic multi-hormonal resistances could be detected. The most conspicuous component of these resistances is insulin resistance, but also leptin, erythropoietin, acetylcholine, triiodothyronine and glucagon-like peptide-1 resistances also occur. On the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854708/ https://www.ncbi.nlm.nih.gov/pubmed/36670938 http://dx.doi.org/10.3390/antiox12010075 |
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author | Wittmann, István |
author_facet | Wittmann, István |
author_sort | Wittmann, István |
collection | PubMed |
description | In diseases with concomitant oxidative stress, chronic multi-hormonal resistances could be detected. The most conspicuous component of these resistances is insulin resistance, but also leptin, erythropoietin, acetylcholine, triiodothyronine and glucagon-like peptide-1 resistances also occur. On the other hand, in oxidative stress, abnormal tyrosines, for instance, meta- and ortho-tyrosine are also produced and incorporated into the proteins through the translational process. In case these modified proteins are components of the intracellular signalling pathways, a hormonal resistance may develop. The above-mentioned hormones, owning overlapping signalling pathways at the insulin receptor substrate, develop an abnormal tyrosine phosphorylation dependent chronic multi-hormonal resistance. A few weeks free of oxidative stress or the use of antioxidant therapy are required to provide a return from this resistance, which return may be further supported by the supplementation of physiological para-tyrosine and by the add-on therapy of a pharmacological dose of glucagon-like peptide-1 receptor agonist, which is able to bypass the critical insulin receptor substrate signalling. |
format | Online Article Text |
id | pubmed-9854708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98547082023-01-21 The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress Wittmann, István Antioxidants (Basel) Review In diseases with concomitant oxidative stress, chronic multi-hormonal resistances could be detected. The most conspicuous component of these resistances is insulin resistance, but also leptin, erythropoietin, acetylcholine, triiodothyronine and glucagon-like peptide-1 resistances also occur. On the other hand, in oxidative stress, abnormal tyrosines, for instance, meta- and ortho-tyrosine are also produced and incorporated into the proteins through the translational process. In case these modified proteins are components of the intracellular signalling pathways, a hormonal resistance may develop. The above-mentioned hormones, owning overlapping signalling pathways at the insulin receptor substrate, develop an abnormal tyrosine phosphorylation dependent chronic multi-hormonal resistance. A few weeks free of oxidative stress or the use of antioxidant therapy are required to provide a return from this resistance, which return may be further supported by the supplementation of physiological para-tyrosine and by the add-on therapy of a pharmacological dose of glucagon-like peptide-1 receptor agonist, which is able to bypass the critical insulin receptor substrate signalling. MDPI 2022-12-29 /pmc/articles/PMC9854708/ /pubmed/36670938 http://dx.doi.org/10.3390/antiox12010075 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wittmann, István The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title | The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title_full | The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title_fullStr | The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title_full_unstemmed | The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title_short | The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress |
title_sort | common single cause of chronic multi-hormonal resistance in oxidative stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854708/ https://www.ncbi.nlm.nih.gov/pubmed/36670938 http://dx.doi.org/10.3390/antiox12010075 |
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