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Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation

Parkinson’s disease (PD) is a dopaminergic neuron-related neurodegenerative illness. Treatments exist that alleviate symptoms but have a variety of negative effects. Recent research has revealed that oxidative stress, along with neuroinflammation, is a major factor in the course of this disease. The...

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Autores principales: Cordaro, Marika, D’Amico, Ramona, Fusco, Roberta, Genovese, Tiziana, Peritore, Alessio Filippo, Gugliandolo, Enrico, Crupi, Rosalia, Di Paola, Davide, Interdonato, Livia, Impellizzeri, Daniela, Cuzzocrea, Salvatore, Di Paola, Rosanna, Siracusa, Rosalba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854773/
https://www.ncbi.nlm.nih.gov/pubmed/36670902
http://dx.doi.org/10.3390/antiox12010040
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author Cordaro, Marika
D’Amico, Ramona
Fusco, Roberta
Genovese, Tiziana
Peritore, Alessio Filippo
Gugliandolo, Enrico
Crupi, Rosalia
Di Paola, Davide
Interdonato, Livia
Impellizzeri, Daniela
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
author_facet Cordaro, Marika
D’Amico, Ramona
Fusco, Roberta
Genovese, Tiziana
Peritore, Alessio Filippo
Gugliandolo, Enrico
Crupi, Rosalia
Di Paola, Davide
Interdonato, Livia
Impellizzeri, Daniela
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
author_sort Cordaro, Marika
collection PubMed
description Parkinson’s disease (PD) is a dopaminergic neuron-related neurodegenerative illness. Treatments exist that alleviate symptoms but have a variety of negative effects. Recent research has revealed that oxidative stress, along with neuroinflammation, is a major factor in the course of this disease. Therefore, the aim of our study was to observe for the first time the effects of a natural compound such as Actaea racemosa L. rhizome in an in vivo model of PD induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). For the study, mice received four injections of MPTP (20 mg/kg) for the induction of PD. Starting 24 h after the first administration of MPTP we treated mice with Actaea racemosa L. rhizome (100 mg/kg) daily for seven days. Our findings clearly demonstrated that Actaea racemosa L. rhizome treatment decreases oxidative stress by activating redox balance enzymes such as Nrf2/HO-1. We also demonstrated that Actaea racemosa L. rhizome is capable of modulating inflammatory indicators involved in PD, such as IκB-α, NF-κB, GFAP and Iba1, thus reducing the degeneration of dopaminergic neurons and motor and non-motor alterations. To summarize, Actaea racemosa L. rhizome, which is subject to fewer regulations than traditional medications, could be used as a dietary supplement to improve patients’ brain health and could be a promising nutraceutical choice to slow the course and symptoms of PD.
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spelling pubmed-98547732023-01-21 Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation Cordaro, Marika D’Amico, Ramona Fusco, Roberta Genovese, Tiziana Peritore, Alessio Filippo Gugliandolo, Enrico Crupi, Rosalia Di Paola, Davide Interdonato, Livia Impellizzeri, Daniela Cuzzocrea, Salvatore Di Paola, Rosanna Siracusa, Rosalba Antioxidants (Basel) Article Parkinson’s disease (PD) is a dopaminergic neuron-related neurodegenerative illness. Treatments exist that alleviate symptoms but have a variety of negative effects. Recent research has revealed that oxidative stress, along with neuroinflammation, is a major factor in the course of this disease. Therefore, the aim of our study was to observe for the first time the effects of a natural compound such as Actaea racemosa L. rhizome in an in vivo model of PD induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). For the study, mice received four injections of MPTP (20 mg/kg) for the induction of PD. Starting 24 h after the first administration of MPTP we treated mice with Actaea racemosa L. rhizome (100 mg/kg) daily for seven days. Our findings clearly demonstrated that Actaea racemosa L. rhizome treatment decreases oxidative stress by activating redox balance enzymes such as Nrf2/HO-1. We also demonstrated that Actaea racemosa L. rhizome is capable of modulating inflammatory indicators involved in PD, such as IκB-α, NF-κB, GFAP and Iba1, thus reducing the degeneration of dopaminergic neurons and motor and non-motor alterations. To summarize, Actaea racemosa L. rhizome, which is subject to fewer regulations than traditional medications, could be used as a dietary supplement to improve patients’ brain health and could be a promising nutraceutical choice to slow the course and symptoms of PD. MDPI 2022-12-25 /pmc/articles/PMC9854773/ /pubmed/36670902 http://dx.doi.org/10.3390/antiox12010040 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cordaro, Marika
D’Amico, Ramona
Fusco, Roberta
Genovese, Tiziana
Peritore, Alessio Filippo
Gugliandolo, Enrico
Crupi, Rosalia
Di Paola, Davide
Interdonato, Livia
Impellizzeri, Daniela
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title_full Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title_fullStr Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title_full_unstemmed Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title_short Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation
title_sort actaea racemosa l. rhizome protect against mptp-induced neurotoxicity in mice by modulating oxidative stress and neuroinflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854773/
https://www.ncbi.nlm.nih.gov/pubmed/36670902
http://dx.doi.org/10.3390/antiox12010040
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