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Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis
Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods:...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854794/ https://www.ncbi.nlm.nih.gov/pubmed/36671377 http://dx.doi.org/10.3390/antibiotics12010176 |
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author | Russo, Emanuele Antonini, Marta Velia Sica, Andrea Dell’Amore, Cristian Martino, Costanza Gamberini, Emiliano Bissoni, Luca Circelli, Alessandro Bolondi, Giuliano Santonastaso, Domenico Pietro Cristini, Francesco Raumer, Luigi Catena, Fausto Agnoletti, Vanni |
author_facet | Russo, Emanuele Antonini, Marta Velia Sica, Andrea Dell’Amore, Cristian Martino, Costanza Gamberini, Emiliano Bissoni, Luca Circelli, Alessandro Bolondi, Giuliano Santonastaso, Domenico Pietro Cristini, Francesco Raumer, Luigi Catena, Fausto Agnoletti, Vanni |
author_sort | Russo, Emanuele |
collection | PubMed |
description | Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods: We conducted a retrospective cohort study aimed to evaluate the incidence of infection-related ventilator-associated complications (IVACs), possible ventilator-associated pneumonia (PVAP), and their characteristics among patients experiencing severe trauma that required ICU admission and IMV for at least four days. We also determined pathogens implicated in PVAP episodes and characterized the use of antimicrobial therapy. Results: In total, 88 adult patients were included in the main analysis. In this study, we observed that 29.5% of patients developed a respiratory infection during ICU stay. Among them, five patients (19.2%) suffered from respiratory infections due to multi-drug resistant bacteria. Patients who developed IVAC/PVAP presented lower total GCS (median value, 7; (IQR, 9) vs. 12.5, (IQR, 8); p = 0.068) than those who did not develop IVAC/PVAP. Conclusions: We observed that less than one-third of trauma patients fulfilling criteria for ventilator associated events developed a respiratory infection during the ICU stay. |
format | Online Article Text |
id | pubmed-9854794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98547942023-01-21 Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis Russo, Emanuele Antonini, Marta Velia Sica, Andrea Dell’Amore, Cristian Martino, Costanza Gamberini, Emiliano Bissoni, Luca Circelli, Alessandro Bolondi, Giuliano Santonastaso, Domenico Pietro Cristini, Francesco Raumer, Luigi Catena, Fausto Agnoletti, Vanni Antibiotics (Basel) Article Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods: We conducted a retrospective cohort study aimed to evaluate the incidence of infection-related ventilator-associated complications (IVACs), possible ventilator-associated pneumonia (PVAP), and their characteristics among patients experiencing severe trauma that required ICU admission and IMV for at least four days. We also determined pathogens implicated in PVAP episodes and characterized the use of antimicrobial therapy. Results: In total, 88 adult patients were included in the main analysis. In this study, we observed that 29.5% of patients developed a respiratory infection during ICU stay. Among them, five patients (19.2%) suffered from respiratory infections due to multi-drug resistant bacteria. Patients who developed IVAC/PVAP presented lower total GCS (median value, 7; (IQR, 9) vs. 12.5, (IQR, 8); p = 0.068) than those who did not develop IVAC/PVAP. Conclusions: We observed that less than one-third of trauma patients fulfilling criteria for ventilator associated events developed a respiratory infection during the ICU stay. MDPI 2023-01-15 /pmc/articles/PMC9854794/ /pubmed/36671377 http://dx.doi.org/10.3390/antibiotics12010176 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Russo, Emanuele Antonini, Marta Velia Sica, Andrea Dell’Amore, Cristian Martino, Costanza Gamberini, Emiliano Bissoni, Luca Circelli, Alessandro Bolondi, Giuliano Santonastaso, Domenico Pietro Cristini, Francesco Raumer, Luigi Catena, Fausto Agnoletti, Vanni Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title_full | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title_fullStr | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title_full_unstemmed | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title_short | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
title_sort | infection-related ventilator-associated complications in critically ill patients with trauma: a retrospective analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854794/ https://www.ncbi.nlm.nih.gov/pubmed/36671377 http://dx.doi.org/10.3390/antibiotics12010176 |
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