Cargando…

The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent worldwide. Despite the different etiologies, their spectra and histological feature are similar, from simple steatosis to more advanced stages such as steatohepatitis, fibrosis, cirrhosis,...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen Huu, Thang, Park, Jiyoung, Zhang, Ying, Duong Thanh, Hien, Park, Iha, Choi, Jin Myung, Yoon, Hyun Joong, Park, Sang Chul, Woo, Hyun Ae, Lee, Seung-Rock
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854873/
https://www.ncbi.nlm.nih.gov/pubmed/36670982
http://dx.doi.org/10.3390/antiox12010120
_version_ 1784873236076429312
author Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Duong Thanh, Hien
Park, Iha
Choi, Jin Myung
Yoon, Hyun Joong
Park, Sang Chul
Woo, Hyun Ae
Lee, Seung-Rock
author_facet Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Duong Thanh, Hien
Park, Iha
Choi, Jin Myung
Yoon, Hyun Joong
Park, Sang Chul
Woo, Hyun Ae
Lee, Seung-Rock
author_sort Nguyen Huu, Thang
collection PubMed
description Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent worldwide. Despite the different etiologies, their spectra and histological feature are similar, from simple steatosis to more advanced stages such as steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Studies including peroxiredoxin knockout models revealed that oxidative stress is crucial in these diseases, which present as consequences of redox imbalance. Protein tyrosine phosphatases (PTPs) are a superfamily of enzymes that are major targets of reactive oxygen species (ROS) because of an oxidation-susceptible nucleophilic cysteine in their active site. Herein, we review the oxidative inactivation of two tumor suppressor PTPs, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and T-cell protein tyrosine phosphatase (TCPTP), and their contribution to the pathogenicity of ALD and NAFLD, respectively. This review might provide a better understanding of the pathogenic mechanisms of these diseases and help develop new therapeutic strategies to treat fatty liver disease.
format Online
Article
Text
id pubmed-9854873
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98548732023-01-21 The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease Nguyen Huu, Thang Park, Jiyoung Zhang, Ying Duong Thanh, Hien Park, Iha Choi, Jin Myung Yoon, Hyun Joong Park, Sang Chul Woo, Hyun Ae Lee, Seung-Rock Antioxidants (Basel) Review Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent worldwide. Despite the different etiologies, their spectra and histological feature are similar, from simple steatosis to more advanced stages such as steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Studies including peroxiredoxin knockout models revealed that oxidative stress is crucial in these diseases, which present as consequences of redox imbalance. Protein tyrosine phosphatases (PTPs) are a superfamily of enzymes that are major targets of reactive oxygen species (ROS) because of an oxidation-susceptible nucleophilic cysteine in their active site. Herein, we review the oxidative inactivation of two tumor suppressor PTPs, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and T-cell protein tyrosine phosphatase (TCPTP), and their contribution to the pathogenicity of ALD and NAFLD, respectively. This review might provide a better understanding of the pathogenic mechanisms of these diseases and help develop new therapeutic strategies to treat fatty liver disease. MDPI 2023-01-03 /pmc/articles/PMC9854873/ /pubmed/36670982 http://dx.doi.org/10.3390/antiox12010120 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen Huu, Thang
Park, Jiyoung
Zhang, Ying
Duong Thanh, Hien
Park, Iha
Choi, Jin Myung
Yoon, Hyun Joong
Park, Sang Chul
Woo, Hyun Ae
Lee, Seung-Rock
The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title_full The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title_fullStr The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title_full_unstemmed The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title_short The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
title_sort role of oxidative inactivation of phosphatase pten and tcptp in fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854873/
https://www.ncbi.nlm.nih.gov/pubmed/36670982
http://dx.doi.org/10.3390/antiox12010120
work_keys_str_mv AT nguyenhuuthang theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parkjiyoung theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT zhangying theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT duongthanhhien theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parkiha theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT choijinmyung theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT yoonhyunjoong theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parksangchul theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT woohyunae theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT leeseungrock theroleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT nguyenhuuthang roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parkjiyoung roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT zhangying roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT duongthanhhien roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parkiha roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT choijinmyung roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT yoonhyunjoong roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT parksangchul roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT woohyunae roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease
AT leeseungrock roleofoxidativeinactivationofphosphataseptenandtcptpinfattyliverdisease