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Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria
In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which res...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854968/ https://www.ncbi.nlm.nih.gov/pubmed/36671310 http://dx.doi.org/10.3390/antibiotics12010109 |
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author | Diyaolu, Oluwatofunmilayo A. Preet, Gagan Fagbemi, Adeshola A. Annang, Frederick Pérez-Moreno, Guiomar Bosch-Navarrete, Cristina Adebisi, Olusoji O. Oluwabusola, Emmanuel T. Milne, Bruce F. Jaspars, Marcel Ebel, Rainer |
author_facet | Diyaolu, Oluwatofunmilayo A. Preet, Gagan Fagbemi, Adeshola A. Annang, Frederick Pérez-Moreno, Guiomar Bosch-Navarrete, Cristina Adebisi, Olusoji O. Oluwabusola, Emmanuel T. Milne, Bruce F. Jaspars, Marcel Ebel, Rainer |
author_sort | Diyaolu, Oluwatofunmilayo A. |
collection | PubMed |
description | In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC(50) values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC(50) values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. |
format | Online Article Text |
id | pubmed-9854968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98549682023-01-21 Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria Diyaolu, Oluwatofunmilayo A. Preet, Gagan Fagbemi, Adeshola A. Annang, Frederick Pérez-Moreno, Guiomar Bosch-Navarrete, Cristina Adebisi, Olusoji O. Oluwabusola, Emmanuel T. Milne, Bruce F. Jaspars, Marcel Ebel, Rainer Antibiotics (Basel) Article In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC(50) values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC(50) values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. MDPI 2023-01-06 /pmc/articles/PMC9854968/ /pubmed/36671310 http://dx.doi.org/10.3390/antibiotics12010109 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Diyaolu, Oluwatofunmilayo A. Preet, Gagan Fagbemi, Adeshola A. Annang, Frederick Pérez-Moreno, Guiomar Bosch-Navarrete, Cristina Adebisi, Olusoji O. Oluwabusola, Emmanuel T. Milne, Bruce F. Jaspars, Marcel Ebel, Rainer Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title_full | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title_fullStr | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title_full_unstemmed | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title_short | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria |
title_sort | antiparasitic activities of compounds isolated from aspergillus fumigatus strain discovered in northcentral nigeria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854968/ https://www.ncbi.nlm.nih.gov/pubmed/36671310 http://dx.doi.org/10.3390/antibiotics12010109 |
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