Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined. Here, we observed a marked reduction in acinar GPX4 expression and ferroptotic cell death in mice wi...

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Detalles Bibliográficos
Autores principales: Ma, Xiaojie, Dong, Xiaowu, Xu, Yao, Ma, Nan, Wei, Mei, Xie, Xiaochun, Lu, Yingying, Cao, Wangsen, Lu, Guotao, Li, Weiqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854988/
https://www.ncbi.nlm.nih.gov/pubmed/36670963
http://dx.doi.org/10.3390/antiox12010100

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