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10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are high...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855106/ https://www.ncbi.nlm.nih.gov/pubmed/36661611 http://dx.doi.org/10.3390/bs13010039 |
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author | Kvašňák, Eugen Magyarová, Eva Domankuš, Miroslav Tesař, Michael Kymplová, Jaroslava Fetissov, Vitaly Abubaker, Mohammed Al Qasem, Wiam |
author_facet | Kvašňák, Eugen Magyarová, Eva Domankuš, Miroslav Tesař, Michael Kymplová, Jaroslava Fetissov, Vitaly Abubaker, Mohammed Al Qasem, Wiam |
author_sort | Kvašňák, Eugen |
collection | PubMed |
description | Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck–Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections. |
format | Online Article Text |
id | pubmed-9855106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98551062023-01-21 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task Kvašňák, Eugen Magyarová, Eva Domankuš, Miroslav Tesař, Michael Kymplová, Jaroslava Fetissov, Vitaly Abubaker, Mohammed Al Qasem, Wiam Behav Sci (Basel) Article Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck–Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections. MDPI 2022-12-31 /pmc/articles/PMC9855106/ /pubmed/36661611 http://dx.doi.org/10.3390/bs13010039 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kvašňák, Eugen Magyarová, Eva Domankuš, Miroslav Tesař, Michael Kymplová, Jaroslava Fetissov, Vitaly Abubaker, Mohammed Al Qasem, Wiam 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title | 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title_full | 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title_fullStr | 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title_full_unstemmed | 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title_short | 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task |
title_sort | 10 minutes frontal 40 hz tacs—effects on working memory tested by luck-vogel task |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855106/ https://www.ncbi.nlm.nih.gov/pubmed/36661611 http://dx.doi.org/10.3390/bs13010039 |
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