Cargando…

10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task

Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are high...

Descripción completa

Detalles Bibliográficos
Autores principales: Kvašňák, Eugen, Magyarová, Eva, Domankuš, Miroslav, Tesař, Michael, Kymplová, Jaroslava, Fetissov, Vitaly, Abubaker, Mohammed, Al Qasem, Wiam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855106/
https://www.ncbi.nlm.nih.gov/pubmed/36661611
http://dx.doi.org/10.3390/bs13010039
_version_ 1784873297579606016
author Kvašňák, Eugen
Magyarová, Eva
Domankuš, Miroslav
Tesař, Michael
Kymplová, Jaroslava
Fetissov, Vitaly
Abubaker, Mohammed
Al Qasem, Wiam
author_facet Kvašňák, Eugen
Magyarová, Eva
Domankuš, Miroslav
Tesař, Michael
Kymplová, Jaroslava
Fetissov, Vitaly
Abubaker, Mohammed
Al Qasem, Wiam
author_sort Kvašňák, Eugen
collection PubMed
description Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck–Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections.
format Online
Article
Text
id pubmed-9855106
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98551062023-01-21 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task Kvašňák, Eugen Magyarová, Eva Domankuš, Miroslav Tesař, Michael Kymplová, Jaroslava Fetissov, Vitaly Abubaker, Mohammed Al Qasem, Wiam Behav Sci (Basel) Article Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck–Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections. MDPI 2022-12-31 /pmc/articles/PMC9855106/ /pubmed/36661611 http://dx.doi.org/10.3390/bs13010039 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kvašňák, Eugen
Magyarová, Eva
Domankuš, Miroslav
Tesař, Michael
Kymplová, Jaroslava
Fetissov, Vitaly
Abubaker, Mohammed
Al Qasem, Wiam
10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title_full 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title_fullStr 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title_full_unstemmed 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title_short 10 Minutes Frontal 40 Hz tACS—Effects on Working Memory Tested by Luck-Vogel Task
title_sort 10 minutes frontal 40 hz tacs—effects on working memory tested by luck-vogel task
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855106/
https://www.ncbi.nlm.nih.gov/pubmed/36661611
http://dx.doi.org/10.3390/bs13010039
work_keys_str_mv AT kvasnakeugen 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT magyarovaeva 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT domankusmiroslav 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT tesarmichael 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT kymplovajaroslava 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT fetissovvitaly 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT abubakermohammed 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask
AT alqasemwiam 10minutesfrontal40hztacseffectsonworkingmemorytestedbyluckvogeltask