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Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. Af...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855215/ https://www.ncbi.nlm.nih.gov/pubmed/36687553 http://dx.doi.org/10.4103/ajts.AJTS_75_20 |
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author | Sheetal, Agarwal Ruby, Singh Dhirendra, P Singh Anubhav, Gupta Devki, Nandan |
author_facet | Sheetal, Agarwal Ruby, Singh Dhirendra, P Singh Anubhav, Gupta Devki, Nandan |
author_sort | Sheetal, Agarwal |
collection | PubMed |
description | Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high. |
format | Online Article Text |
id | pubmed-9855215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-98552152023-01-21 Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge Sheetal, Agarwal Ruby, Singh Dhirendra, P Singh Anubhav, Gupta Devki, Nandan Asian J Transfus Sci Case Report Tuberculosis (TB) has varied manifestations, but autoimmune hemolytic anemia (AIHA) due to TB is rare. Direct antibody test (DAT) or Coombs negative AIHA is also rare. We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high. Wolters Kluwer - Medknow 2022 2022-05-26 /pmc/articles/PMC9855215/ /pubmed/36687553 http://dx.doi.org/10.4103/ajts.AJTS_75_20 Text en Copyright: © 2022 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Sheetal, Agarwal Ruby, Singh Dhirendra, P Singh Anubhav, Gupta Devki, Nandan Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title | Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title_full | Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title_fullStr | Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title_full_unstemmed | Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title_short | Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge |
title_sort | direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: a diagnostic challenge |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855215/ https://www.ncbi.nlm.nih.gov/pubmed/36687553 http://dx.doi.org/10.4103/ajts.AJTS_75_20 |
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