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Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy

CONTEXT: Resistant pathogens to purulent odontogenic infections have evolved due to misuse of antibiotics. Hence, it is important to use a suitable antibacterial agent. AIM: This study aimed to identify the common bacterial species causing odontogenic infections and to determine their antibiotic sus...

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Autores principales: Judith, M Jemima, Aswath, Nalini, Padmavathy, Kesavaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855256/
https://www.ncbi.nlm.nih.gov/pubmed/36687001
http://dx.doi.org/10.4103/ccd.ccd_782_21
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author Judith, M Jemima
Aswath, Nalini
Padmavathy, Kesavaram
author_facet Judith, M Jemima
Aswath, Nalini
Padmavathy, Kesavaram
author_sort Judith, M Jemima
collection PubMed
description CONTEXT: Resistant pathogens to purulent odontogenic infections have evolved due to misuse of antibiotics. Hence, it is important to use a suitable antibacterial agent. AIM: This study aimed to identify the common bacterial species causing odontogenic infections and to determine their antibiotic susceptibility profile to amoxicillin, amoxicillin and clavulanic acid, azithromycin, and linezolid. SETTINGS AND DESIGN: This was an in vitro cross-sectional study. MATERIAL AND METHODS: Fifty pus samples from odontogenic abscess were cultured and antibiotic susceptibility tests were performed as per the standard microbiological procedures. STATISTICAL ANALYSIS USED: Binomial test and Pearson's Chi-square test were used for statistical analysis. RESULTS: Out of the 50 samples cultured, 30 samples showed growth. The distribution of growth among the 30 samples was Gram-positive cocci (n = 23, 67.65%) and Gram-negative bacilli (n = 11, 32.35%). Gram-positive isolates that were grown were Enterococcus faecalis (38.24%) followed by Staphylococcus aureus (29.41%) and Gram-negative bacilli that were isolated were Klebsiella pneumoniae (14.71%), Pseudomonas aeruginosa (8.82%), Escherichia coli (5.88%), and Enterobacter (2.94%). Enterococcus isolates were highly susceptible to amoxicillin (76.92%). An increase in the zone of inhibition to amoxicillin–clavulanic acid was appreciated more for Staphylococcus (50%) than Enterococcus (30.76%). Enterococcus and Staphylococcus showed high susceptibility of 92.31% and 90% to linezolid, respectively. E. coli and Enterobacter were 100% susceptible to amoxicillin. All the Gram-negative bacteria except for P. aeruginosa were 100% highly susceptible to amoxicillin–clavulanic acid. CONCLUSIONS: Culture-guided antibiotic prescriptions are necessary to prevent the emergence of antibiotic-resistant bacteria.
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spelling pubmed-98552562023-01-21 Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy Judith, M Jemima Aswath, Nalini Padmavathy, Kesavaram Contemp Clin Dent Original Article CONTEXT: Resistant pathogens to purulent odontogenic infections have evolved due to misuse of antibiotics. Hence, it is important to use a suitable antibacterial agent. AIM: This study aimed to identify the common bacterial species causing odontogenic infections and to determine their antibiotic susceptibility profile to amoxicillin, amoxicillin and clavulanic acid, azithromycin, and linezolid. SETTINGS AND DESIGN: This was an in vitro cross-sectional study. MATERIAL AND METHODS: Fifty pus samples from odontogenic abscess were cultured and antibiotic susceptibility tests were performed as per the standard microbiological procedures. STATISTICAL ANALYSIS USED: Binomial test and Pearson's Chi-square test were used for statistical analysis. RESULTS: Out of the 50 samples cultured, 30 samples showed growth. The distribution of growth among the 30 samples was Gram-positive cocci (n = 23, 67.65%) and Gram-negative bacilli (n = 11, 32.35%). Gram-positive isolates that were grown were Enterococcus faecalis (38.24%) followed by Staphylococcus aureus (29.41%) and Gram-negative bacilli that were isolated were Klebsiella pneumoniae (14.71%), Pseudomonas aeruginosa (8.82%), Escherichia coli (5.88%), and Enterobacter (2.94%). Enterococcus isolates were highly susceptible to amoxicillin (76.92%). An increase in the zone of inhibition to amoxicillin–clavulanic acid was appreciated more for Staphylococcus (50%) than Enterococcus (30.76%). Enterococcus and Staphylococcus showed high susceptibility of 92.31% and 90% to linezolid, respectively. E. coli and Enterobacter were 100% susceptible to amoxicillin. All the Gram-negative bacteria except for P. aeruginosa were 100% highly susceptible to amoxicillin–clavulanic acid. CONCLUSIONS: Culture-guided antibiotic prescriptions are necessary to prevent the emergence of antibiotic-resistant bacteria. Wolters Kluwer - Medknow 2022 2022-11-03 /pmc/articles/PMC9855256/ /pubmed/36687001 http://dx.doi.org/10.4103/ccd.ccd_782_21 Text en Copyright: © 2022 Contemporary Clinical Dentistry https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Judith, M Jemima
Aswath, Nalini
Padmavathy, Kesavaram
Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title_full Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title_fullStr Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title_full_unstemmed Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title_short Microbiota of Dental Abscess and their Susceptibility to Empirical Antibiotic Therapy
title_sort microbiota of dental abscess and their susceptibility to empirical antibiotic therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855256/
https://www.ncbi.nlm.nih.gov/pubmed/36687001
http://dx.doi.org/10.4103/ccd.ccd_782_21
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