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1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT(6)R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-HT(6)R) recruits additional signaling pathways that control cognitive function, brain development, and synaptic plasticity in an agonist-dependent and independent manner. Considering that aberrant constitutive...

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Detalles Bibliográficos
Autores principales:	Canale, Vittorio, Trybała, Wojciech, Chaumont-Dubel, Séverine, Koczurkiewicz-Adamczyk, Paulina, Satała, Grzegorz, Bento, Ophélie, Blicharz-Futera, Klaudia, Bantreil, Xavier, Pękala, Elżbieta, Bojarski, Andrzej J., Lamaty, Frédéric, Marin, Philippe, Zajdel, Paweł
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855333/ https://www.ncbi.nlm.nih.gov/pubmed/36671397 http://dx.doi.org/10.3390/biom13010012

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