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Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study

There are few studies on dementia and schizophrenia in older patients looking for structural differences. This paper aims to describe relation between cognitive performance and brain volumes in older schizophrenia patients. Twenty schizophrenic outpatients —10 without-dementia (SND), 10 with dementi...

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Autores principales: Rivas, Juan, Gutierrez-Gomez, Santiago, Villanueva-Congote, Juliana, Libreros, Jose, Camprodon, Joan Albert, Trujillo, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855401/
https://www.ncbi.nlm.nih.gov/pubmed/36672741
http://dx.doi.org/10.3390/biomedicines11010233
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author Rivas, Juan
Gutierrez-Gomez, Santiago
Villanueva-Congote, Juliana
Libreros, Jose
Camprodon, Joan Albert
Trujillo, María
author_facet Rivas, Juan
Gutierrez-Gomez, Santiago
Villanueva-Congote, Juliana
Libreros, Jose
Camprodon, Joan Albert
Trujillo, María
author_sort Rivas, Juan
collection PubMed
description There are few studies on dementia and schizophrenia in older patients looking for structural differences. This paper aims to describe relation between cognitive performance and brain volumes in older schizophrenia patients. Twenty schizophrenic outpatients —10 without-dementia (SND), 10 with dementia (SD)— and fifteen healthy individuals —as the control group (CG)—, older than 50, were selected. Neuropsychological tests were used to examine cognitive domains. Brain volumes were calculated with magnetic resonance images. Cognitive performance was significantly better in CG than in schizophrenics. Cognitive performance was worst in SD than SND, except in semantic memory and visual attention. Hippocampal volumes showed significant differences between SD and CG, with predominance on the right side. Left thalamic volume was smaller in SD group than in SND. Structural differences were found in the hippocampus, amygdala, and thalamus; more evident in the amygdala and thalamus, which were mainly related to dementia. In conclusion, cognitive performance and structural changes allowed us to differentiate between schizophrenia patients and CG, with changes being more pronounced in SD than in SND. When comparing SND with SD, the functional alterations largely coincide, although sometimes in the opposite direction. Moreover, volume lost in the hippocampus, amygdala, and thalamus may be related to the possibility to develop dementia in schizophrenic patients.
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spelling pubmed-98554012023-01-21 Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study Rivas, Juan Gutierrez-Gomez, Santiago Villanueva-Congote, Juliana Libreros, Jose Camprodon, Joan Albert Trujillo, María Biomedicines Article There are few studies on dementia and schizophrenia in older patients looking for structural differences. This paper aims to describe relation between cognitive performance and brain volumes in older schizophrenia patients. Twenty schizophrenic outpatients —10 without-dementia (SND), 10 with dementia (SD)— and fifteen healthy individuals —as the control group (CG)—, older than 50, were selected. Neuropsychological tests were used to examine cognitive domains. Brain volumes were calculated with magnetic resonance images. Cognitive performance was significantly better in CG than in schizophrenics. Cognitive performance was worst in SD than SND, except in semantic memory and visual attention. Hippocampal volumes showed significant differences between SD and CG, with predominance on the right side. Left thalamic volume was smaller in SD group than in SND. Structural differences were found in the hippocampus, amygdala, and thalamus; more evident in the amygdala and thalamus, which were mainly related to dementia. In conclusion, cognitive performance and structural changes allowed us to differentiate between schizophrenia patients and CG, with changes being more pronounced in SD than in SND. When comparing SND with SD, the functional alterations largely coincide, although sometimes in the opposite direction. Moreover, volume lost in the hippocampus, amygdala, and thalamus may be related to the possibility to develop dementia in schizophrenic patients. MDPI 2023-01-16 /pmc/articles/PMC9855401/ /pubmed/36672741 http://dx.doi.org/10.3390/biomedicines11010233 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rivas, Juan
Gutierrez-Gomez, Santiago
Villanueva-Congote, Juliana
Libreros, Jose
Camprodon, Joan Albert
Trujillo, María
Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title_full Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title_fullStr Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title_full_unstemmed Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title_short Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study
title_sort subcortical structures in demented schizophrenia patients: a comparative study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855401/
https://www.ncbi.nlm.nih.gov/pubmed/36672741
http://dx.doi.org/10.3390/biomedicines11010233
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