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Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to ident...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855433/ https://www.ncbi.nlm.nih.gov/pubmed/36672624 http://dx.doi.org/10.3390/biomedicines11010116 |
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author | Giusca, Simona Eliza Andriescu, Elena Corina Caruntu, Irina Draga Ciobanu, Delia |
author_facet | Giusca, Simona Eliza Andriescu, Elena Corina Caruntu, Irina Draga Ciobanu, Delia |
author_sort | Giusca, Simona Eliza |
collection | PubMed |
description | Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to identify criteria that could predict increased aggressiveness. We analyzed 59 consecutive MTC cases. We focused on the relationships among clinicopathological characteristics, parameters of aggressiveness (extrathyroidal extension, lymphovascular invasion, and lymph node metastasis), and parameters for MTC grading. Statistically significant correlations were found for tumor size, lymphovascular invasion, and lymph node metastasis and tumor focality and lymph node metastasis. Our results showed, in tumors larger than 40 mm, odds ratios (ODs) of 13.695 and 6 for lymphovascular invasion and lymph node metastasis, respectively; in multifocal tumors, we registered an OD of 9.42 for lymph node metastasis. No significant correlation was found for the parameters of the MTC grading system when assessed individually and integrated by reporting low-grade and high-grade risk groups. Although our data indicate that lymphovascular invasion and lymph node metastasis remain significant markers for aggressiveness, studies on larger series of cases are mandatory to detect and validate new factors responsible for the variable course of MTC. |
format | Online Article Text |
id | pubmed-9855433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98554332023-01-21 Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? Giusca, Simona Eliza Andriescu, Elena Corina Caruntu, Irina Draga Ciobanu, Delia Biomedicines Article Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to identify criteria that could predict increased aggressiveness. We analyzed 59 consecutive MTC cases. We focused on the relationships among clinicopathological characteristics, parameters of aggressiveness (extrathyroidal extension, lymphovascular invasion, and lymph node metastasis), and parameters for MTC grading. Statistically significant correlations were found for tumor size, lymphovascular invasion, and lymph node metastasis and tumor focality and lymph node metastasis. Our results showed, in tumors larger than 40 mm, odds ratios (ODs) of 13.695 and 6 for lymphovascular invasion and lymph node metastasis, respectively; in multifocal tumors, we registered an OD of 9.42 for lymph node metastasis. No significant correlation was found for the parameters of the MTC grading system when assessed individually and integrated by reporting low-grade and high-grade risk groups. Although our data indicate that lymphovascular invasion and lymph node metastasis remain significant markers for aggressiveness, studies on larger series of cases are mandatory to detect and validate new factors responsible for the variable course of MTC. MDPI 2023-01-03 /pmc/articles/PMC9855433/ /pubmed/36672624 http://dx.doi.org/10.3390/biomedicines11010116 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Giusca, Simona Eliza Andriescu, Elena Corina Caruntu, Irina Draga Ciobanu, Delia Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title | Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title_full | Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title_fullStr | Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title_full_unstemmed | Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title_short | Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? |
title_sort | clinicopathological profile of medullary thyroid carcinoma—could we predict aggressive behavior? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855433/ https://www.ncbi.nlm.nih.gov/pubmed/36672624 http://dx.doi.org/10.3390/biomedicines11010116 |
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