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Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?

Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to ident...

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Autores principales: Giusca, Simona Eliza, Andriescu, Elena Corina, Caruntu, Irina Draga, Ciobanu, Delia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855433/
https://www.ncbi.nlm.nih.gov/pubmed/36672624
http://dx.doi.org/10.3390/biomedicines11010116
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author Giusca, Simona Eliza
Andriescu, Elena Corina
Caruntu, Irina Draga
Ciobanu, Delia
author_facet Giusca, Simona Eliza
Andriescu, Elena Corina
Caruntu, Irina Draga
Ciobanu, Delia
author_sort Giusca, Simona Eliza
collection PubMed
description Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to identify criteria that could predict increased aggressiveness. We analyzed 59 consecutive MTC cases. We focused on the relationships among clinicopathological characteristics, parameters of aggressiveness (extrathyroidal extension, lymphovascular invasion, and lymph node metastasis), and parameters for MTC grading. Statistically significant correlations were found for tumor size, lymphovascular invasion, and lymph node metastasis and tumor focality and lymph node metastasis. Our results showed, in tumors larger than 40 mm, odds ratios (ODs) of 13.695 and 6 for lymphovascular invasion and lymph node metastasis, respectively; in multifocal tumors, we registered an OD of 9.42 for lymph node metastasis. No significant correlation was found for the parameters of the MTC grading system when assessed individually and integrated by reporting low-grade and high-grade risk groups. Although our data indicate that lymphovascular invasion and lymph node metastasis remain significant markers for aggressiveness, studies on larger series of cases are mandatory to detect and validate new factors responsible for the variable course of MTC.
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spelling pubmed-98554332023-01-21 Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior? Giusca, Simona Eliza Andriescu, Elena Corina Caruntu, Irina Draga Ciobanu, Delia Biomedicines Article Medullary thyroid carcinoma (MTC) accounts for only 2–5% of all thyroid malignancies. Clinical and pathological characteristics alone may suffice to predict outcomes, but unstable behavior in some cases suggests that other factors may influence a worse course of the disease. This study aims to identify criteria that could predict increased aggressiveness. We analyzed 59 consecutive MTC cases. We focused on the relationships among clinicopathological characteristics, parameters of aggressiveness (extrathyroidal extension, lymphovascular invasion, and lymph node metastasis), and parameters for MTC grading. Statistically significant correlations were found for tumor size, lymphovascular invasion, and lymph node metastasis and tumor focality and lymph node metastasis. Our results showed, in tumors larger than 40 mm, odds ratios (ODs) of 13.695 and 6 for lymphovascular invasion and lymph node metastasis, respectively; in multifocal tumors, we registered an OD of 9.42 for lymph node metastasis. No significant correlation was found for the parameters of the MTC grading system when assessed individually and integrated by reporting low-grade and high-grade risk groups. Although our data indicate that lymphovascular invasion and lymph node metastasis remain significant markers for aggressiveness, studies on larger series of cases are mandatory to detect and validate new factors responsible for the variable course of MTC. MDPI 2023-01-03 /pmc/articles/PMC9855433/ /pubmed/36672624 http://dx.doi.org/10.3390/biomedicines11010116 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Giusca, Simona Eliza
Andriescu, Elena Corina
Caruntu, Irina Draga
Ciobanu, Delia
Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title_full Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title_fullStr Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title_full_unstemmed Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title_short Clinicopathological Profile of Medullary Thyroid Carcinoma—Could We Predict Aggressive Behavior?
title_sort clinicopathological profile of medullary thyroid carcinoma—could we predict aggressive behavior?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855433/
https://www.ncbi.nlm.nih.gov/pubmed/36672624
http://dx.doi.org/10.3390/biomedicines11010116
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