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Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855440/ https://www.ncbi.nlm.nih.gov/pubmed/36671401 http://dx.doi.org/10.3390/biom13010016 |
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author | Bottino-Rojas, Vanessa James, Anthony A. |
author_facet | Bottino-Rojas, Vanessa James, Anthony A. |
author_sort | Bottino-Rojas, Vanessa |
collection | PubMed |
description | Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes with robust sex-, tissue- and stage-specific expression profiles have supported the development of new tools and strategies that could bring mosquito-borne diseases under control. Although the list of regulatory elements available is significant, only a limited set of those can reliably drive spatial–temporal expression. Here, we review the advances in our ability to express beneficial and other genes in mosquitoes, and highlight the information needed for the development of new mosquito-control and anti-disease strategies. |
format | Online Article Text |
id | pubmed-9855440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98554402023-01-21 Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases Bottino-Rojas, Vanessa James, Anthony A. Biomolecules Review Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes with robust sex-, tissue- and stage-specific expression profiles have supported the development of new tools and strategies that could bring mosquito-borne diseases under control. Although the list of regulatory elements available is significant, only a limited set of those can reliably drive spatial–temporal expression. Here, we review the advances in our ability to express beneficial and other genes in mosquitoes, and highlight the information needed for the development of new mosquito-control and anti-disease strategies. MDPI 2022-12-21 /pmc/articles/PMC9855440/ /pubmed/36671401 http://dx.doi.org/10.3390/biom13010016 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bottino-Rojas, Vanessa James, Anthony A. Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title | Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title_full | Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title_fullStr | Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title_full_unstemmed | Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title_short | Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases |
title_sort | use of insect promoters in genetic engineering to control mosquito-borne diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855440/ https://www.ncbi.nlm.nih.gov/pubmed/36671401 http://dx.doi.org/10.3390/biom13010016 |
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