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Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases

Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes...

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Detalles Bibliográficos
Autores principales: Bottino-Rojas, Vanessa, James, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855440/
https://www.ncbi.nlm.nih.gov/pubmed/36671401
http://dx.doi.org/10.3390/biom13010016
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author Bottino-Rojas, Vanessa
James, Anthony A.
author_facet Bottino-Rojas, Vanessa
James, Anthony A.
author_sort Bottino-Rojas, Vanessa
collection PubMed
description Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes with robust sex-, tissue- and stage-specific expression profiles have supported the development of new tools and strategies that could bring mosquito-borne diseases under control. Although the list of regulatory elements available is significant, only a limited set of those can reliably drive spatial–temporal expression. Here, we review the advances in our ability to express beneficial and other genes in mosquitoes, and highlight the information needed for the development of new mosquito-control and anti-disease strategies.
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spelling pubmed-98554402023-01-21 Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases Bottino-Rojas, Vanessa James, Anthony A. Biomolecules Review Mosquito transgenesis and gene-drive technologies provide the basis for developing promising new tools for vector-borne disease prevention by either suppressing wild mosquito populations or reducing their capacity from transmitting pathogens. Many studies of the regulatory DNA and promoters of genes with robust sex-, tissue- and stage-specific expression profiles have supported the development of new tools and strategies that could bring mosquito-borne diseases under control. Although the list of regulatory elements available is significant, only a limited set of those can reliably drive spatial–temporal expression. Here, we review the advances in our ability to express beneficial and other genes in mosquitoes, and highlight the information needed for the development of new mosquito-control and anti-disease strategies. MDPI 2022-12-21 /pmc/articles/PMC9855440/ /pubmed/36671401 http://dx.doi.org/10.3390/biom13010016 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bottino-Rojas, Vanessa
James, Anthony A.
Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title_full Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title_fullStr Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title_full_unstemmed Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title_short Use of Insect Promoters in Genetic Engineering to Control Mosquito-Borne Diseases
title_sort use of insect promoters in genetic engineering to control mosquito-borne diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855440/
https://www.ncbi.nlm.nih.gov/pubmed/36671401
http://dx.doi.org/10.3390/biom13010016
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