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The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury

The endocannabinoid (EC) system is a complex cell-signaling system that participates in a vast number of biological processes since the prenatal period, including the development of the nervous system, brain plasticity, and circuit repair. This neuromodulatory system is also involved in the response...

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Autores principales: Duranti, Andrea, Beldarrain, Gorane, Álvarez, Antonia, Sbriscia, Matilde, Carloni, Silvia, Balduini, Walter, Alonso-Alconada, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855621/
https://www.ncbi.nlm.nih.gov/pubmed/36672536
http://dx.doi.org/10.3390/biomedicines11010028
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author Duranti, Andrea
Beldarrain, Gorane
Álvarez, Antonia
Sbriscia, Matilde
Carloni, Silvia
Balduini, Walter
Alonso-Alconada, Daniel
author_facet Duranti, Andrea
Beldarrain, Gorane
Álvarez, Antonia
Sbriscia, Matilde
Carloni, Silvia
Balduini, Walter
Alonso-Alconada, Daniel
author_sort Duranti, Andrea
collection PubMed
description The endocannabinoid (EC) system is a complex cell-signaling system that participates in a vast number of biological processes since the prenatal period, including the development of the nervous system, brain plasticity, and circuit repair. This neuromodulatory system is also involved in the response to endogenous and environmental insults, being of special relevance in the prevention and/or treatment of vascular disorders, such as stroke and neuroprotection after neonatal brain injury. Perinatal hypoxia–ischemia leading to neonatal encephalopathy is a devastating condition with no therapeutic approach apart from moderate hypothermia, which is effective only in some cases. This overview, therefore, gives a current description of the main components of the EC system (including cannabinoid receptors, ligands, and related enzymes), to later analyze the EC system as a target for neonatal neuroprotection with a special focus on its neurogenic potential after hypoxic–ischemic brain injury.
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spelling pubmed-98556212023-01-21 The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury Duranti, Andrea Beldarrain, Gorane Álvarez, Antonia Sbriscia, Matilde Carloni, Silvia Balduini, Walter Alonso-Alconada, Daniel Biomedicines Review The endocannabinoid (EC) system is a complex cell-signaling system that participates in a vast number of biological processes since the prenatal period, including the development of the nervous system, brain plasticity, and circuit repair. This neuromodulatory system is also involved in the response to endogenous and environmental insults, being of special relevance in the prevention and/or treatment of vascular disorders, such as stroke and neuroprotection after neonatal brain injury. Perinatal hypoxia–ischemia leading to neonatal encephalopathy is a devastating condition with no therapeutic approach apart from moderate hypothermia, which is effective only in some cases. This overview, therefore, gives a current description of the main components of the EC system (including cannabinoid receptors, ligands, and related enzymes), to later analyze the EC system as a target for neonatal neuroprotection with a special focus on its neurogenic potential after hypoxic–ischemic brain injury. MDPI 2022-12-22 /pmc/articles/PMC9855621/ /pubmed/36672536 http://dx.doi.org/10.3390/biomedicines11010028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Duranti, Andrea
Beldarrain, Gorane
Álvarez, Antonia
Sbriscia, Matilde
Carloni, Silvia
Balduini, Walter
Alonso-Alconada, Daniel
The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title_full The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title_fullStr The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title_full_unstemmed The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title_short The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury
title_sort endocannabinoid system as a target for neuroprotection/neuroregeneration in perinatal hypoxic–ischemic brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855621/
https://www.ncbi.nlm.nih.gov/pubmed/36672536
http://dx.doi.org/10.3390/biomedicines11010028
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