Cargando…

Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients

Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center...

Descripción completa

Detalles Bibliográficos
Autores principales: Figueras Castilla, Albert, Ballesteros Vizoso, María A., Iglesias Coma, Amanda, Barceló, Antonia, Barea-Mendoza, Jesús A., Argente del Castillo, Paula, Guardiola, Begoña, Pérez-Bárcena, Jon, Llompart-Pou, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855627/
https://www.ncbi.nlm.nih.gov/pubmed/36672534
http://dx.doi.org/10.3390/biomedicines11010026
_version_ 1784873424310501376
author Figueras Castilla, Albert
Ballesteros Vizoso, María A.
Iglesias Coma, Amanda
Barceló, Antonia
Barea-Mendoza, Jesús A.
Argente del Castillo, Paula
Guardiola, Begoña
Pérez-Bárcena, Jon
Llompart-Pou, Juan A.
author_facet Figueras Castilla, Albert
Ballesteros Vizoso, María A.
Iglesias Coma, Amanda
Barceló, Antonia
Barea-Mendoza, Jesús A.
Argente del Castillo, Paula
Guardiola, Begoña
Pérez-Bárcena, Jon
Llompart-Pou, Juan A.
author_sort Figueras Castilla, Albert
collection PubMed
description Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center study. We studied the relationship between continuous variables by using Pearson correlation and simple linear regression. Multiple logistic regression analysis was performed to analyze the factors independently associated with mortality. Seventy-eight patients were included in the study at intensive care unit (ICU) admission and 72 had a measurement of the thyroid and inflammatory profile at day 5. No significant correlations were found between thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and inflammatory cytokines at ICU admission. At day 5, fT4, was inversely correlated with IL-10 (p = 0.035). IL-10 was associated with maximum lactate (p < 0.001) and SOFA score values (p = 0.012). The multiple logistic regression analysis showed that there was a significant relationship between IL-10 (day 5) and in-hospital mortality after adjusting by age and severity of illness. In conclusion, we found that the thyroid hormone profile and inflammatory cytokines had a weak correlation at ICU admission. Associations of interest between fT4 and IL-10 were found at day 5. IL-10 at day 5 was found to be correlated with low fT4 and markers of organ failure and death.
format Online
Article
Text
id pubmed-9855627
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98556272023-01-21 Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients Figueras Castilla, Albert Ballesteros Vizoso, María A. Iglesias Coma, Amanda Barceló, Antonia Barea-Mendoza, Jesús A. Argente del Castillo, Paula Guardiola, Begoña Pérez-Bárcena, Jon Llompart-Pou, Juan A. Biomedicines Article Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center study. We studied the relationship between continuous variables by using Pearson correlation and simple linear regression. Multiple logistic regression analysis was performed to analyze the factors independently associated with mortality. Seventy-eight patients were included in the study at intensive care unit (ICU) admission and 72 had a measurement of the thyroid and inflammatory profile at day 5. No significant correlations were found between thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and inflammatory cytokines at ICU admission. At day 5, fT4, was inversely correlated with IL-10 (p = 0.035). IL-10 was associated with maximum lactate (p < 0.001) and SOFA score values (p = 0.012). The multiple logistic regression analysis showed that there was a significant relationship between IL-10 (day 5) and in-hospital mortality after adjusting by age and severity of illness. In conclusion, we found that the thyroid hormone profile and inflammatory cytokines had a weak correlation at ICU admission. Associations of interest between fT4 and IL-10 were found at day 5. IL-10 at day 5 was found to be correlated with low fT4 and markers of organ failure and death. MDPI 2022-12-22 /pmc/articles/PMC9855627/ /pubmed/36672534 http://dx.doi.org/10.3390/biomedicines11010026 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Figueras Castilla, Albert
Ballesteros Vizoso, María A.
Iglesias Coma, Amanda
Barceló, Antonia
Barea-Mendoza, Jesús A.
Argente del Castillo, Paula
Guardiola, Begoña
Pérez-Bárcena, Jon
Llompart-Pou, Juan A.
Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title_full Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title_fullStr Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title_full_unstemmed Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title_short Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients
title_sort correlation between thyroid responses and inflammatory cytokines in critically ill covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855627/
https://www.ncbi.nlm.nih.gov/pubmed/36672534
http://dx.doi.org/10.3390/biomedicines11010026
work_keys_str_mv AT figuerascastillaalbert correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT ballesterosvizosomariaa correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT iglesiascomaamanda correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT barceloantonia correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT bareamendozajesusa correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT argentedelcastillopaula correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT guardiolabegona correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT perezbarcenajon correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients
AT llompartpoujuana correlationbetweenthyroidresponsesandinflammatorycytokinesincriticallyillcovid19patients