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Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach
Objective. Transcranial electrical stimulation (tES) is a promising method for modulating brain activity and excitability with variable results to date. To minimize electric (E-)field strength variability, we introduce the 2-sample prospective E-field dosing (2-SPED) approach, which uses E-field str...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOP Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855635/ https://www.ncbi.nlm.nih.gov/pubmed/36240729 http://dx.doi.org/10.1088/1741-2552/ac9a78 |
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author | Van Hoornweder, Sybren A Caulfield, Kevin Nitsche, Michael Thielscher, Axel L J Meesen, Raf |
author_facet | Van Hoornweder, Sybren A Caulfield, Kevin Nitsche, Michael Thielscher, Axel L J Meesen, Raf |
author_sort | Van Hoornweder, Sybren |
collection | PubMed |
description | Objective. Transcranial electrical stimulation (tES) is a promising method for modulating brain activity and excitability with variable results to date. To minimize electric (E-)field strength variability, we introduce the 2-sample prospective E-field dosing (2-SPED) approach, which uses E-field strengths induced by tES in a first population to individualize stimulation intensity in a second population. Approach. We performed E-field modeling of three common tES montages in 300 healthy younger adults. First, permutation analyses identified the sample size required to obtain a stable group average E-field in the primary motor cortex (M1), with stability being defined as the number of participants where all group-average E-field strengths ± standard deviation did not leave the population’s 5–95 percentile range. Second, this stable group average was used to individualize tES intensity in a second independent population (n = 100). The impact of individualized versus fixed intensity tES on E-field strength variability was analyzed. Main results. In the first population, stable group average E-field strengths (V/m) in M1 were achieved at 74–85 participants, depending on the tES montage. Individualizing the stimulation intensity (mA) in the second population resulted in uniform M1 E-field strength (all p < 0.001) and significantly diminished peak cortical E-field strength variability (all p < 0.01), across all montages. Significance. 2-SPED is a feasible way to prospectively induce more uniform E-field strengths in a region of interest. Future studies might apply 2-SPED to investigate whether decreased E-field strength variability also results in decreased physiological and behavioral variability in response to tES. |
format | Online Article Text |
id | pubmed-9855635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IOP Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-98556352023-01-23 Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach Van Hoornweder, Sybren A Caulfield, Kevin Nitsche, Michael Thielscher, Axel L J Meesen, Raf J Neural Eng Paper Objective. Transcranial electrical stimulation (tES) is a promising method for modulating brain activity and excitability with variable results to date. To minimize electric (E-)field strength variability, we introduce the 2-sample prospective E-field dosing (2-SPED) approach, which uses E-field strengths induced by tES in a first population to individualize stimulation intensity in a second population. Approach. We performed E-field modeling of three common tES montages in 300 healthy younger adults. First, permutation analyses identified the sample size required to obtain a stable group average E-field in the primary motor cortex (M1), with stability being defined as the number of participants where all group-average E-field strengths ± standard deviation did not leave the population’s 5–95 percentile range. Second, this stable group average was used to individualize tES intensity in a second independent population (n = 100). The impact of individualized versus fixed intensity tES on E-field strength variability was analyzed. Main results. In the first population, stable group average E-field strengths (V/m) in M1 were achieved at 74–85 participants, depending on the tES montage. Individualizing the stimulation intensity (mA) in the second population resulted in uniform M1 E-field strength (all p < 0.001) and significantly diminished peak cortical E-field strength variability (all p < 0.01), across all montages. Significance. 2-SPED is a feasible way to prospectively induce more uniform E-field strengths in a region of interest. Future studies might apply 2-SPED to investigate whether decreased E-field strength variability also results in decreased physiological and behavioral variability in response to tES. IOP Publishing 2022-10-01 2022-10-28 /pmc/articles/PMC9855635/ /pubmed/36240729 http://dx.doi.org/10.1088/1741-2552/ac9a78 Text en © 2022 The Author(s). Published by IOP Publishing Ltd https://creativecommons.org/licenses/by/4.0/ Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license (https://creativecommons.org/licenses/by/4.0/) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
spellingShingle | Paper Van Hoornweder, Sybren A Caulfield, Kevin Nitsche, Michael Thielscher, Axel L J Meesen, Raf Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title_full | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title_fullStr | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title_full_unstemmed | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title_short | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach |
title_sort | addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-sped approach |
topic | Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855635/ https://www.ncbi.nlm.nih.gov/pubmed/36240729 http://dx.doi.org/10.1088/1741-2552/ac9a78 |
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